Growth hormone variant; GH-V; Growth hormone 2; Placenta-specific growth hormone; GH2

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This GH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-45 amino acids from the N-terminal region of human GH2.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-GH2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The protein encoded by this gene is a member of the
somatotropin/prolactin family of hormones which play an important
role in growth control. The gene, along with four other related
genes, is located at the growth hormone locus on chromosome 17
where they are interspersed in the same transcriptional
orientation; an arrangement which is thought to have evolved by a
series of gene duplications. The five genes share a remarkably high
degree of sequence identity. Alternative splicing generates
additional isoforms of each of the five growth hormones, leading to
further diversity and potential for specialization. As in the case
of its pituitary counterpart, growth hormone 1, the predominant
isoform of this particular family member shows similar somatogenic
activity, with reduced lactogenic activity. Mutations in this gene
lead to placental growth hormone/lactogen deficiency. [provided by
RefSeq].

Signal Transduction

Western Blot (WB), ELISA (EIA)

WB~~1:1000

GH2 Antibody (N-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the GH2 antibody detected the GH2 protein (arrow).

25000

growth hormone 2

growth hormone variant

Growth hormone variant

GH-V??[Similar Products]

SOM2_HUMAN

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency. [provided by RefSeq, Jul 2008]

GH2: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Belongs to the somatotropin/prolactin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 17q24.2

Cellular Component: extracellular region

Molecular Function: hormone activity

McElholm, A.R., et al. Gastroenterology 139(1):204-212(2010)
de Jesus Romero-Prado, M.M., et al. Gene 452(1):7-15(2010)
Christiansen, M. Prenat. Diagn. 29(13):1249-1255(2009)
Zeck, W., et al. Pediatr. Res. 63(4):353-357(2008)
Mittal, P., et al. J. Matern. Fetal. Neonatal. Med. 20(9):651-659(2007)

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