For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Purified by peptide affinity column containing 1% BSA and 0.02% NaN3

Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at-20 degree C.

Small volumes of anti-ANGPTL6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Rabbit polyclonal ANGPTL6(1) antibody was raised against a 16 amino acid peptide from near the N terminal of human ASNS protein.

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

Peptide ELISA (EIA), Western Blot (WB)

Peptide ELISA: 1:5,000-1:20,000
WB: 1:200-1,000

57,100 Da

solute carrier family 1 member 1

excitatory amino acid transporter 3

Excitatory amino acid transporter 3

EAAC1; EAAT3??[Similar Products]

This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010]

Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7914198, PubMed:7521911, PubMed:8857541, PubMed:26690923, PubMed:21123949). Can also transport L-cysteine (PubMed:21123949). Functions as a symporter that transports one amino acid molecule together with two or three Na+ ions and one proton, in parallel with the counter-transport of one K+ ion (PubMed:7521911, PubMed:8857541, PubMed:26690923). Mediates Cl- flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na+ symport (PubMed:8857541, PubMed:26690923). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:21123949). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (). Negatively regulated by ARL6IP5 ().

(1) Strausberg, R.L., Feingold, E.A., Grouse, L.H., Derge, J.G., et al. Generation and initial analysis of more than 15, 000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002).

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