Product Name
Carbonic Anhydrase III (CA3), Monoclonal Antibody
Full Product Name
Carbonic Anhydrase III (CA3, Carbonic anhydrase III, muscle specific CAIII, CA-III, Car3, Carbonate dehydratase III, Carbonic anhydrase 3, Carbonic anhydrase II)
Product Synonym Names
Anti -Carbonic Anhydrase III (CA3, Carbonic anhydrase III, muscle specific CAIII, CA-III, Car3, Carbonate dehydratase III, Carbonic anhydrase 3, Carbonic anhydrase II)
Product Gene Name
anti-CA3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 8; NC_000008.10 (86351056..86361269). Location: 8q21.2
3D Structure
ModBase 3D Structure for P07451
Specificity
Recognizes human CA3.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a lyophilized powder in 0.2um sterile-filtered solution in PBS, pH7.2, 5% trehalose. Reconstitute with 40-50% glycerol, PBS.
Immunogen
Recombinant human CA3, aa2-260; P07451 (E. coli)
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile 40-50% glycerol, PBS.. Aliquot and store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-CA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CA3 antibody
Carbonic Anhydrase is a group of metalloproteases that catalyze the reversible reaction of CO2 + H2O = HCO3- + H+, which is fundamental to many processes such as respiration, renal tubular acidification and bone resorption. CA3 is a cytosolic enzyme with a very low CA activity. It is present at high levels in skeletal muscle and much lower levels in other tissues, such as cardiac and smooth muscle. The aa sequence of human CA3 is 99%, 90% and 92% identical to that of chimpanzee, dog and mouse/rat.
Product Categories/Family for anti-CA3 antibody
Antibodies; Abs to Enzymes
Applications Tested/Suitable for anti-CA3 antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-CA3 antibody
Suitable for use in Western Blot and Immunoprecipitation.
Dilution: Western Blot: 2ug/ml
NCBI/Uniprot data below describe general gene information for CA3. It may not necessarily be applicable to this product.
UniProt Primary Accession #
P07451
[Other Products]
UniProt Secondary Accession #
O60842; B2R867; B3KUC8[Other Products]
UniProt Related Accession #
P07451[Other Products]
Molecular Weight
29,557 Da[Similar Products]
NCBI Official Full Name
carbonic anhydrase III
NCBI Official Synonym Full Names
carbonic anhydrase III, muscle specific
NCBI Official Symbol
CA3??[Similar Products]
NCBI Official Synonym Symbols
Car3; CAIII; FLJ36434
??[Similar Products]
NCBI Protein Information
carbonic anhydrase 3; CA-III; OTTHUMP00000227990; carbonate dehydratase III
UniProt Protein Name
Carbonic anhydrase 3
UniProt Synonym Protein Names
Carbonate dehydratase III; Carbonic anhydrase III
Protein Family
Carbonic anhydrase
UniProt Gene Name
CA3??[Similar Products]
UniProt Entry Name
CAH3_HUMAN
NCBI Summary for CA3
Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encodes carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. The gene spans 10.3 kb and contains seven exons and six introns. [provided by RefSeq]
UniProt Comments for CA3
CA3: Reversible hydration of carbon dioxide. Belongs to the alpha-carbonic anhydrase family.
Protein type: EC 4.2.1.1; Lyase; Energy Metabolism - nitrogen
Chromosomal Location of Human Ortholog: 8q21.2
Cellular Component: cytosol
Molecular Function: carbonate dehydratase activity; zinc ion binding; nickel ion binding
Biological Process: response to ethanol; bicarbonate transport; one-carbon compound metabolic process; response to oxidative stress
Research Articles on CA3
1. The level of CAIII is specifically insufficient in the skeletal muscle of myasthenia gravis patients.
Precautions
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Disclaimer
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