For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

This product is specific for Arginine Vasopressin Receptor (AVPR-V2). The immunising peptide has no significant similarity with AVP V1a or V1b receptors.

Purified
Purified IgG - liquid

IgG concentration 1.0 mg/ml (lot specific)

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Small volumes of anti-Avpr2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This product is specific for Arginine Vasopressin Receptor (AVPR-V2). The immunising peptide has no significant similarity with AVP V1a or V1b receptors.

Immunohistology Frozen, ELISA (EIA), Western Blot (WB)

Western Blot: A glycosylated band at approximately 62 kD is observed using membranes from rat inner medulla. N-Glycanase reduces the size of this band to 36 kD (deglycosylated form).

40,749 Da[Similar Products]

arginine vasopressin receptor 2

vasopressin V2 receptor; AVPR V2; V2R; Vasopressin receptor V2; antidiuretic hormone receptor; renal-type arginine vasopressin receptor

Vasopressin V2 receptor

V2R??[Similar Products]

V2R_RAT

G-protein coupled receptor for arginine vasopressin; responsible for mediation of antidiuretic effect and changes in blood pressure [RGD, Feb 2006]

AVPR2: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption. Defects in AVPR2 are the cause of nephrogenic syndrome of inappropriate antidiuresis (NSIAD). This disorder is characterized by an inability to excrete a free water load, with inappropriately concentrated urine and resultant hyponatremia, hypoosmolarity, and natriuresis. Defects in AVPR2 are the cause of diabetes insipidus nephrogenic X-linked (XNDI); also known as diabetes insipidus nephrogenic type 1. XNDI is caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. It is characterized by excessive water drinking (polydypsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Transporter; Transporter, aquaporin family

Cellular Component: integral to plasma membrane; integral to membrane; intracellular

Molecular Function: peptide hormone binding; vasopressin receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; I-kappaB kinase/NF-kappaB cascade; telencephalon development; regulation of systemic arterial blood pressure by vasopressin; response to cytokine stimulus; positive regulation of cell proliferation; positive regulation of vasoconstriction; interferon-gamma production; positive regulation of systemic arterial blood pressure; positive regulation of blood pressure; cellular response to hormone stimulus

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.