Full Product Name
BSND Antibody - middle region
Product Gene Name
anti-BSND antibody
[Similar Products]
Product Synonym Gene Name
BART; DFNB73[Similar Products]
Antibody/Peptide Pairs
BSND peptide (MBS3239342) is used for blocking the activity of BSND antibody (MBS3214405)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: PGDVQAWMEA AVVIHKGSDE SEGERRLTQS WPGPLACPQG PAPLASFQDD
3D Structure
ModBase 3D Structure for Q8WZ55
Species Reactivity
Human, Pig
Purity/Purification
Affinity purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Human: 100%; Pig: 77%
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human BSND
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-BSND antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BSND antibody
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
Target Description: This gene encodes an essential beta subunit for CLC chloride channels. These heteromeric channels localize to basolateral membranes of renal tubules and of potassium-secreting epithelia of the inner ear. Mutations in this gene have been associated with Bartter syndrome with sensorineural deafness.
Product Categories/Family for anti-BSND antibody
Polyclonal; Ion Channel; Disease Related; Tissue Specific & Cell Marker;
Western Blot (WB) of anti-BSND antibody
Host: Rabbit
Target Name: BSND
Sample Tissue: Human Liver Tumor lysates
Antibody Dilution: 1ug/ml
NCBI/Uniprot data below describe general gene information for BSND. It may not necessarily be applicable to this product.
NCBI Accession #
NP_476517
[Other Products]
NCBI GenBank Nucleotide #
NM_057176.2.
[Other Products]
UniProt Primary Accession #
Q8WZ55
[Other Products]
UniProt Related Accession #
Q8WZ55[Other Products]
NCBI Official Full Name
barttin
NCBI Official Synonym Full Names
barttin CLCNK type accessory beta subunit
NCBI Official Symbol
BSND??[Similar Products]
NCBI Official Synonym Symbols
BART; DFNB73
??[Similar Products]
NCBI Protein Information
barttin
UniProt Protein Name
Barttin
UniProt Gene Name
BSND??[Similar Products]
UniProt Synonym Gene Names
BART??[Similar Products]
UniProt Entry Name
BSND_HUMAN
NCBI Summary for BSND
This gene encodes an essential beta subunit for CLC chloride channels. These heteromeric channels localize to basolateral membranes of renal tubules and of potassium-secreting epithelia of the inner ear. Mutations in this gene have been associated with Bartter syndrome with sensorineural deafness. [provided by RefSeq, Jul 2008]
UniProt Comments for BSND
BSND: Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter. Defects in BSND are the cause of Bartter syndrome type 4A (BS4A); also known as infantile Bartter syndrome with sensorineural deafness. BS refers to a group of autosomal recessive disorders characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BS4A is associated with sensorineural deafness.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: 1p32.1
Cellular Component: protein complex; integral to plasma membrane; basolateral plasma membrane; cytoplasm; plasma membrane
Molecular Function: chloride channel activity; chloride channel regulator activity
Biological Process: transmembrane transport
Disease: Bartter Syndrome, Type 4a
Research Articles on BSND
1. Increasing expression of barttin over that of ClC-K partially recovered this insufficiency, indicating that N-terminal modifications of barttin alter both binding affinities and gating properties
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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