Product Name
RBP, Native Protein
Full Product Name
RBP protein (> 95% pure)
Product Synonym Names
Retinol Binding Protein
Product Gene Name
RBP native protein
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
> 95% pure
Form/Format
Supplied as a liquid in 2mM NH4(C(=O)OHO).
Source Note
Urine of patients with chronic renal tubular proteinuria
Biological Significance
Retinol-binding proteins are a family of proteins with diverse functions. They are carrier proteins that bind retinol.
Biohazard Information
Donor samples were tested and found to be negative for ?HIV I/II, and HCV antibodies, and Hepatitis B surface antigen. Nonetheless caution should be used when handling this material as there is a margin of error in all tests.
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of RBP native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
RBP native protein
Highly purified native Human RBP protein
Product Categories/Family for RBP native protein
Nutrition & Metabolism; Native Protein
Applications Tested/Suitable for RBP native protein
User optimized
NCBI/Uniprot data below describe general gene information for RBP. It may not necessarily be applicable to this product.
NCBI Accession #
AAA59188.1
[Other Products]
UniProt Secondary Accession #
Q0QD34; Q5VSR0; Q8IXN0[Other Products]
UniProt Related Accession #
P10745[Other Products]
NCBI Official Full Name
retinol-binding protein
NCBI Official Synonym Full Names
retinol binding protein 3, interstitial
NCBI Official Symbol
RBP3??[Similar Products]
NCBI Official Synonym Symbols
IRBP; RBPI; RP66; D10S64; D10S65; D10S66
??[Similar Products]
NCBI Protein Information
retinol-binding protein 3
UniProt Protein Name
Retinol-binding protein 3
UniProt Synonym Protein Names
Interphotoreceptor retinoid-binding protein; IRBP; Interstitial retinol-binding protein
Protein Family
Receptor binding protein
UniProt Gene Name
RBP3??[Similar Products]
UniProt Synonym Gene Names
IRBP??[Similar Products]
UniProt Entry Name
RET3_HUMAN
NCBI Summary for RBP
Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively. [provided by RefSeq, Jul 2008]
UniProt Comments for RBP
RBP3: IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina. Belongs to the peptidase S41A family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 10q11.2
Cellular Component: extracellular space; extracellular region; vesicle
Molecular Function: retinoid binding; serine-type peptidase activity; retinol binding; retinal binding
Biological Process: phototransduction, visible light; visual perception; transport; lipid metabolic process; proteolysis; retinoid metabolic process
Disease: Retinitis Pigmentosa 66; Retinitis Pigmentosa
Research Articles on RBP
1. We found that most patients with macular telangiectasia-2 possess retinal autoantibodies, the most prevalent of which were directed against AGL, RBP3, and CK-B.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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