Product Name
Alpha 1 Antitrypsin (SERPINA1), Native Protein
Full Product Name
Purified native Human Alpha 1 Antitrypsin protein
Product Synonym Names
Alpha 1 Antitrypsin protein
Product Gene Name
SERPINA1 native protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P01009
Purity/Purification
> 95% pure
Concentration
1.0 mg/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C for short term storage. For long term storage aliquot and store at -20 degree C.
Other Notes
Small volumes of SERPINA1 native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for SERPINA1 native protein
Proteases; Inhibitors; & Enzymes
NCBI/Uniprot data below describe general gene information for SERPINA1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001121179.1
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NCBI GenBank Nucleotide #
NM_001127707.1
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UniProt Primary Accession #
P01009
[Other Products]
UniProt Secondary Accession #
Q0PVP5; Q13672; Q53XB8; Q5U0M1; Q7M4R2; Q86U18; Q86U19; Q96BF9; Q96ES1; A6PX14; B2RDQ8[Other Products]
UniProt Related Accession #
P01009[Other Products]
Molecular Weight
34,755 Da[Similar Products]
NCBI Official Full Name
alpha-1-antitrypsin
NCBI Official Synonym Full Names
serpin family A member 1
NCBI Official Symbol
SERPINA1??[Similar Products]
NCBI Official Synonym Symbols
PI; A1A; AAT; PI1; A1AT; PRO2275; alpha1AT
??[Similar Products]
NCBI Protein Information
alpha-1-antitrypsin
UniProt Protein Name
Alpha-1-antitrypsin
UniProt Synonym Protein Names
Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1
Protein Family
Alpha-1-antitrypsin
UniProt Gene Name
SERPINA1??[Similar Products]
UniProt Synonym Gene Names
AAT; PI; SPAAT??[Similar Products]
NCBI Summary for SERPINA1
The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for SERPINA1
Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.
Research Articles on SERPINA1
1. The Alpha-1 antitrypsin (A1AT) deficiency (A1ATD) is a genetic autosomal recessive disease, characterized by low serum levels of A1AT.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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