Product Name
Adenylate Kinase 2 (mAK2), Recombinant Protein
Full Product Name
Recombinant Mouse Adenylate Kinase 2
Product Synonym Names
Adenylate kinase 2 mitochondrial isoform a; Ak-2; D4Ertd220e, mitochondrial; ATP-AMP transphosphorylase 2; ATP:AMP phosphotransferas; Adenylate monophosphate kinase; AK2 Mouse; Adenylate Kinase 2 Mouse Recombinant
Product Gene Name
mAK2 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MGSSHHHHHH SSGLVPRGSH MGSH MAPNVL ASEPEIPKGI RAVLLGPPGA GKGTQAPKLA ENFCVCHLAT GDMLRAMVAS GSEL TMDAGKLVSD EMVVELIEKN LETPSCKNGF LLDGFPRTVR QAEMLDDLME KRKEKLDSVI EFSIQDSLLI RRITGRLIHP KSGRSNPPKE PMKDD ITGEPLIRRS DDNEKALKTR LEAYHTQTTP LVEYYRKRGI HCAIDASQTP DIVFASILAA FSKATCKDLV MFI
3D Structure
ModBase 3D Structure for Q9WTP6
Purity/Purification
Greater than 95.0% as determined by SDS-PAGE
Form/Format
Sterile filtered colorless solution
Protein solution (0.5mg/ml) containing 20mM Tris-Hcl buffer (pH8.5), 10% glycerol and 1mM DTT
Biological Activity
Specific activity is > 40 units/mg. One unit will convert 2.0 umoles of ADP to ATP + AMP per minute at pH 7.5 at 37C
Preparation and Storage
Although stable at 4 degree C for 1 week, should be stored below-18 degree C. Please prevent freeze thaw cycles
Other Notes
Small volumes of mAK2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
mAK2 recombinant protein
Description: AK2 Mouse Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 263 amino acids (1-239 a.a) and having a molecular mass of 29kDa. AK2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction: Adenylate kinases play a role in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. There are 3 types of adenylate kinase isozymes, AK1, AK2, and AK3 in vertebrates. Expression of these isozymes are tissue-specific and developmentally regulated. AK2 is localized in the mitochondrial intermembrane space and is involved in apoptosis. AK2 is mutated in individuals with reticular dysgenesis.
Product Categories/Family for mAK2 recombinant protein
PROTEIN KINASES; Enzymes; Adenylate Kinase; AK2 Mouse
NCBI/Uniprot data below describe general gene information for mAK2. It may not necessarily be applicable to this product.
NCBI Accession #
Q9WTP6.5
[Other Products]
UniProt Primary Accession #
Q9WTP6
[Other Products]
UniProt Secondary Accession #
Q3THT3; Q3TI11; Q3TKI6; Q8C7I9; Q9CY37; A2A820[Other Products]
UniProt Related Accession #
Q9WTP6[Other Products]
Molecular Weight
25,606 Da
NCBI Official Full Name
Adenylate kinase 2, mitochondrial
NCBI Official Synonym Full Names
adenylate kinase 2
NCBI Official Symbol
Ak2??[Similar Products]
NCBI Official Synonym Symbols
Ak-2; D4Ertd220e
??[Similar Products]
NCBI Protein Information
adenylate kinase 2, mitochondrial
UniProt Protein Name
Adenylate kinase 2, mitochondrial
UniProt Synonym Protein Names
ATP-AMP transphosphorylase 2
Protein Family
Adenylate kinase
UniProt Gene Name
Ak2??[Similar Products]
UniProt Synonym Gene Names
AK 2??[Similar Products]
UniProt Comments for mAK2
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
Research Articles on mAK2
1. results suggest that AK2 is an associated activator of DUSP26 and suppresses cell proliferation by FADD dephosphorylation, postulating AK2 as a negative regulator of tumour growth.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
