Full Product Name
ALS2 Antibody
Product Gene Name
anti-ALS2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human
Predicted: Mouse, Rat
Form/Format
Purified by protein affinity column containing 1% BSA and 0.02% NaN3
Preparation and Storage
Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at-20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.
Other Notes
Small volumes of anti-ALS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ALS2 antibody
Rabbit polyclonal ALS2 (1) antibody was raised against a recombinate human ALS2 protein 177-414aa (BC029174).
Product Categories/Family for anti-ALS2 antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-ALS2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ALS2 antibody
ELISA: 1:20,000-1:80,000
WB: 1:1,000-1:2,000
IHC: 1:100-1:500
Testing Data of anti-ALS2 antibody
Testing Data of anti-ALS2 antibody
NCBI/Uniprot data below describe general gene information for ALS2. It may not necessarily be applicable to this product.
NCBI Accession #
BC029174
[Other Products]
UniProt Secondary Accession #
Q53TT1; Q53TV2; Q8N1E0; Q96PC4; Q96Q41; Q9H973; Q9HCK9[Other Products]
UniProt Related Accession #
Q96Q42[Other Products]
Molecular Weight
86,782 Da
NCBI Official Full Name
Homo sapiens amyotrophic lateral sclerosis 2 (juvenile), mRNA
NCBI Official Synonym Full Names
ALS2, alsin Rho guanine nucleotide exchange factor
NCBI Official Symbol
ALS2??[Similar Products]
NCBI Official Synonym Symbols
ALSJ; PLSJ; IAHSP; ALS2CR6
??[Similar Products]
NCBI Protein Information
alsin
UniProt Protein Name
Alsin
UniProt Synonym Protein Names
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein; Amyotrophic lateral sclerosis 2 protein
UniProt Gene Name
ALS2??[Similar Products]
UniProt Synonym Gene Names
ALS2CR6; KIAA1563??[Similar Products]
NCBI Summary for ALS2
The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
UniProt Comments for ALS2
May act as a GTPase regulator. Controls survival and growth of spinal motoneurons ().
Product References and Citations for anti-ALS2 antibody
(1) Rose, J.E., Behm, F.M., Drgon, T., et al. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Mol. Med. 16 (7-8), 247-253 (2010).
Research Articles on ALS2
1. Nonsense mutation in ALS2 gene is associated with severe and progressive infantile onset of spastic paralysis.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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