Anti -CABC1, CT (D531) (Chaperone-activity of BC1 Complex-like, Mitochondrial, Chaperone-ABC1-like, aarF Domain-containing Protein Kinase 3, ADCK3, PP265)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 1; NC_000001.10 (227084589..227091365). Location: 1q42.13

Polyclonal

IgG

Rabbit

Recognizes human CABC1.

Purified
Purified by ammonium sulfate precipitation.

Supplied as a liquid in PBS, 0.09% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-ADCK3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

CABC1 is one of several proteins for which expression is induced by p53 expression. The S. pombe homolog, ABC1, is a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain.

Antibodies; Abs to Protein Kinases

ELISA (EL/EIA), Western Blot (WB)

Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

71,950 Da[Similar Products]

aarF domain containing kinase 3

chaperone activity of bc1 complex-like, mitochondrial; OTTHUMP00000035734; OTTHUMP00000035735; OTTHUMP00000035736; OTTHUMP00000035737; OTTHUMP00000038685; coenzyme Q8 homolog; aarF domain-containing protein kinase 3; chaperone, ABC1 activity of bc1 complex homolog

Chaperone activity of bc1 complex-like, mitochondrial

CABC1??[Similar Products]

ADCK3_HUMAN

This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined. [provided by RefSeq]

ADCK3: May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain. Defects in ADCK3 are the cause of coenzyme Q10 deficiency, primary, type 4 (COQ10D4). An autosomal recessive disorder characterized by childhood-onset of cerebellar ataxia and exercise intolerance. Patient manifest gait ataxia and cerebellar atrophy with slow progression. Additional features include brisk tendon reflexes and Hoffmann sign, variable psychomotor retardation and variable seizures. Belongs to the protein kinase superfamily. ADCK protein kinase family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.-; Protein kinase, atypical; Kinase, protein; ATYPICAL group; ABC1 family; ABC1-A subfamily

Chromosomal Location of Human Ortholog: 1q42.13

Cellular Component: mitochondrion

Molecular Function: protein serine/threonine kinase activity; ATP binding

Biological Process: ubiquinone biosynthetic process; protein amino acid phosphorylation

Disease: Coenzyme Q10 Deficiency, Primary, 4

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