Bone morphogenetic protein receptor type-1A; BMP type-1A receptor; BMPR-1A; Activin receptor-like kinase 3; ALK-3; BMP-2/BMP-4 receptor; Serine/threonine-protein kinase receptor R5; SKR5; CD292; Bmpr1a; Acvrlk3; Bmpr

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This Mouse Bmpr1a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 170-197 amino acids from the Central region of mouse Bmpr1a.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-Bmpr1a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4.

Cardiovascular; Metabolism; Signal Transduction

Western Blot (WB), ELISA (EIA)

WB~~1:1000

Mouse Bmpr1a Antibody (Center) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the Bmpr1a antibody detected the Bmpr1a protein (arrow).

60063

bone morphogenetic protein receptor, type 1A

bone morphogenetic protein receptor type-1A

Bone morphogenetic protein receptor type-1A

Acvrlk3; Bmpr; BMP type-1A receptor; BMPR-1A; ALK-3; SKR5??[Similar Products]

BMR1A_MOUSE

BMPR1A: a serine/threonine-protein kinase receptor for Bone morphogenetic protein-2 and -4 (BMP-2 and BMP-4). Defects in BMPR1A are a cause of juvenile polyposis syndrome (JPS) and Cowden disease (CD), a cancer syndrome characterized by multiple hamartomas and by a high risk for breast, thyroid and endometriel cancers.

Protein type: Membrane protein, integral; EC 2.7.11.30; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Kinase, protein; TKL group; STKR family; Type1 subfamily

Cellular Component: membrane; cell soma; dendrite; integral to membrane; plasma membrane; caveola

Molecular Function: transferase activity; protein serine/threonine kinase activity; protein homodimerization activity; metal ion binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; SMAD binding; ATP binding; transmembrane receptor protein serine/threonine kinase activity; protein kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: transcription from RNA polymerase II promoter; neural plate mediolateral pattern formation; heart morphogenesis; paraxial mesoderm development; developmental growth; hindlimb morphogenesis; neural crest cell development; positive regulation of transcription, DNA-dependent; heart development; mesendoderm development; paraxial mesoderm structural organization; dorsal/ventral axis specification; palate development; protein amino acid phosphorylation; negative regulation of neurogenesis; anterior/posterior pattern formation; BMP signaling pathway; transmembrane receptor protein serine/threonine kinase signaling pathway; positive regulation of mesenchymal cell proliferation; ectoderm development; embryonic morphogenesis; cell differentiation; Mullerian duct regression; nervous system development; regulation of endothelial cell proliferation; somitogenesis; in utero embryonic development; stem cell maintenance; lateral mesoderm development; positive regulation of bone mineralization; pattern specification process; regulation of endothelial cell differentiation; odontogenesis of dentine-containing teeth; positive regulation of osteoblast differentiation; mesoderm formation; dorsal/ventral pattern formation; pituitary gland development; cartilage development; embryonic organ development; immune response; embryonic digit morphogenesis; phosphorylation; regulation of lateral mesodermal cell fate specification; positive regulation of epithelial cell proliferation; lung development; endoderm development

Drogat, B., et al. Blood 116(12):2141-2151(2010)
Leung, A.W., et al. Dev. Dyn. 239(9):2319-2329(2010)
Mira, H., et al. Cell Stem Cell 7(1):78-89(2010)
Libusova, L., et al. Development 137(14):2297-2305(2010)
Caronia, G., et al. J. Neurosci. 30(18):6291-6301(2010)

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