Bone morphogenetic protein receptor type-1A; BMP type-1A receptor; BMPR-1A; Activin receptor-like kinase 3; ALK-3; BMP-2/BMP-4 receptor; Serine/threonine-protein kinase receptor R5; SKR5; CD292; Bmpr1a; Acvrlk3; Bmpr

For Research Use Only. Not for use in diagnostic procedures.

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Small volumes of Bmpr1a blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4.

60,063 Da

bone morphogenetic protein receptor, type 1A

bone morphogenetic protein receptor type-1A

Bone morphogenetic protein receptor type-1A

Acvrlk3; Bmpr; BMP type-1A receptor; BMPR-1A; ALK-3; SKR5??[Similar Products]

BMR1A_MOUSE

BMPR1A: a serine/threonine-protein kinase receptor for Bone morphogenetic protein-2 and -4 (BMP-2 and BMP-4). Defects in BMPR1A are a cause of juvenile polyposis syndrome (JPS) and Cowden disease (CD), a cancer syndrome characterized by multiple hamartomas and by a high risk for breast, thyroid and endometriel cancers.

Protein type: Protein kinase, TKL; Kinase, protein; EC 2.7.11.30; Protein kinase, Ser/Thr (receptor); Membrane protein, integral; TKL group; STKR family; Type1 subfamily

Cellular Component: caveola; cell soma; dendrite; external side of plasma membrane; plasma membrane

Molecular Function: ATP binding; glycoprotein binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; SMAD binding

Biological Process: anterior/posterior pattern formation; BMP signaling pathway; cartilage development; cell differentiation; chondrocyte differentiation; developmental growth; dorsal/ventral axis specification; dorsal/ventral pattern formation; ectoderm development; embryonic digit morphogenesis; embryonic morphogenesis; embryonic organ development; endoderm development; heart development; heart morphogenesis; hindlimb morphogenesis; immune response; in utero embryonic development; lateral mesoderm development; lung development; mesendoderm development; mesoderm formation; Mullerian duct regression; negative regulation of neurogenesis; nervous system development; neural crest cell development; neural plate mediolateral pattern formation; odontogenesis of dentine-containing teeth; palate development; paraxial mesoderm development; paraxial mesoderm structural organization; pattern specification process; pituitary gland development; positive regulation of bone mineralization; positive regulation of epithelial cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; regulation of endothelial cell differentiation; regulation of endothelial cell proliferation; regulation of lateral mesodermal cell fate specification; somitogenesis; stem cell maintenance

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