Product Name
Kallikrein-11 (KLK11), Recombinant Protein
Full Product Name
Recombinant Human Kallikrein-11 (KLK11)
Product Gene Name
KLK11 recombinant protein
[Similar Products]
Product Synonym Gene Name
KLK11[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
54-282aa, Full Length of Mature Protein
Sequence
IIKGFECKPH SQPWQAALFE KTRLLCGATL IAPRWLLTAA HCLKPRYIVH LGQHNLQKEE GCEQTRTATE SFPHPGFNNS LPNKDHRNDI MLVKMASPVS ITWAVRPLTL SSRCVTAGTS CLISGWGSTS SPQLRLPHTL RCANITIIEH QKCENAYPGN ITDTMVCASV QEGGKDSCQG DSGGPLVCNQ SLQGIISWGQ DPCAITRKPG VYTKVCKYVD WIQETMKNN
3D Structure
ModBase 3D Structure for Q9UBX7
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of KLK11 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for KLK11. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001129504.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001136032.2
[Other Products]
UniProt Primary Accession #
Q9UBX7
[Other Products]
UniProt Secondary Accession #
O75837; Q0WXX5; Q8IXD7; Q9NS65[Other Products]
UniProt Related Accession #
Q9UBX7[Other Products]
Molecular Weight
30,166 Da
NCBI Official Full Name
kallikrein-11 isoform 1
NCBI Official Synonym Full Names
kallikrein related peptidase 11
NCBI Official Symbol
KLK11??[Similar Products]
NCBI Official Synonym Symbols
TLSP; PRSS20
??[Similar Products]
NCBI Protein Information
kallikrein-11
UniProt Protein Name
Kallikrein-11
UniProt Synonym Protein Names
Hippostasin; Serine protease 20; Trypsin-like protease
Protein Family
Kallikrein
UniProt Gene Name
KLK11??[Similar Products]
UniProt Synonym Gene Names
PRSS20; TLSP; hK11??[Similar Products]
NCBI Summary for KLK11
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternate promoters results in multiple transcript variants encoding distinct isoforms which are differentially expressed. [provided by RefSeq, Dec 2016]
UniProt Comments for KLK11
Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.
Research Articles on KLK11
1. Pronounced correlations between KLK10/KLK11 (rs = 0.647) and between KLK9/KLK15 (rs = 0.716) mRNA, but not between other combinations, indicate coordinate expression of distinct pairs of peptidases
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
