Product Name
ATF7IP, Polyclonal Antibody
Full Product Name
ATF7IP Polyclonal Antibody
Product Synonym Names
AM; ATF-IP; MCAF; MCAF1; p621
Product Gene Name
anti-ATF7IP antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
NEKDNKPEEE EQVIHEDDER PSEKNEFSRR KRSKSEDMDN VQSKRRRYME EEYEAEFQVK ITAKGDINQK LQKVIQWLLE EKLCALQCAV FDKTLAELKT RVEKIECNKR HKTVLTELQA KIARLTKRFE AAKEDLKKRH EHPPNPPVSP GKTVNDVNSN NNMSYRNAGT VRQMLESKRN VSESAPPSFQ TPVNTVSSTN L
3D Structure
ModBase 3D Structure for Q6VMQ6
Purity/Purification
Affinity Purification
Immunogen
Recombinant protein of human ATF7IP
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Cellular Location
Nucleus
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Other Notes
Small volumes of anti-ATF7IP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-ATF7IP antibody
Polyclonal Antibodies
Applications Tested/Suitable for anti-ATF7IP antibody
Immunohistochemistry (IHC)
Application Notes for anti-ATF7IP antibody
IHC: 1:50 - 1:200
NCBI/Uniprot data below describe general gene information for ATF7IP. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001273443.1
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NCBI GenBank Nucleotide #
NM_001286514.1
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UniProt Primary Accession #
Q6VMQ6
[Other Products]
UniProt Secondary Accession #
Q4G0T9; Q6P3T3; Q86XW5; Q9NVJ9; Q9NWC2; Q9Y4X8; F5GX74; G3V1U0[Other Products]
UniProt Related Accession #
Q6VMQ6[Other Products]
Molecular Weight
118kDa/136kDa/137kDa
NCBI Official Full Name
activating transcription factor 7-interacting protein 1 isoform 3
NCBI Official Synonym Full Names
activating transcription factor 7 interacting protein
NCBI Official Symbol
ATF7IP??[Similar Products]
NCBI Official Synonym Symbols
AM; MCAF; p621; MCAF1; ATF-IP
??[Similar Products]
NCBI Protein Information
activating transcription factor 7-interacting protein 1
UniProt Protein Name
Activating transcription factor 7-interacting protein 1
UniProt Synonym Protein Names
ATF-interacting protein; ATF-IP; ATF7-interacting protein; ATFa-associated modulator; hAM; MBD1-containing chromatin-associated factor 1; P621
Protein Family
Activating transcription factor 7-interacting protein
UniProt Gene Name
ATF7IP??[Similar Products]
UniProt Synonym Gene Names
MCAF; MCAF1; ATF-IP; hAM??[Similar Products]
NCBI Summary for ATF7IP
ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. It can act as a transcriptional coactivator or corepressor depending upon its binding partners (summary by Liu et al., 2009 [PubMed 19106100]).[supplied by OMIM, Nov 2010]
UniProt Comments for ATF7IP
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells.
Research Articles on ATF7IP
1. Here we report on a special case of a Ph-like acute lymphoblastic leukemia patient who had a variant ATF7IP/PDGFRB fusion. In this case, a variant fusion was created between ATF7IP exon 9 (instead of exon 13) and PDGFRB exon 11, resulting in the loss of 411 nucleotides and 137 amino acids in the ATF7IP/PDGFRB fusion cDNA and its encoded chimeric protein, respectively.
Precautions
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Disclaimer
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