Product Name
IL-36gamma (IL36G), Recombinant Protein
Full Product Name
IL-36gamma(169a.a.), human
Product Gene Name
IL36G recombinant protein
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Other Notes
Small volumes of IL36G recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for IL36G. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001265497.1
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NCBI GenBank Nucleotide #
NM_001278568.1
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UniProt Secondary Accession #
Q56B91; Q6UVX7; Q7RTZ9[Other Products]
UniProt Related Accession #
Q9NZH8[Other Products]
Molecular Weight
14,928 Da[Similar Products]
NCBI Official Full Name
interleukin-36 gamma isoform 2
NCBI Official Synonym Full Names
interleukin 36, gamma
NCBI Official Symbol
IL36G??[Similar Products]
NCBI Official Synonym Symbols
IL1E; IL1F9; IL1H1; IL-1F9; IL-1H1; IL1RP2; IL-1RP2
??[Similar Products]
NCBI Protein Information
interleukin-36 gamma
UniProt Protein Name
Interleukin-36 gamma
UniProt Synonym Protein Names
IL-1-related protein 2; IL-1RP2; Interleukin-1 epsilon; IL-1 epsilon; Interleukin-1 family member 9; IL-1F9; Interleukin-1 homolog 1; IL-1H1
Protein Family
Interleukin
UniProt Gene Name
IL36G??[Similar Products]
UniProt Synonym Gene Names
IL1E; IL1F9; IL1H1; IL1RP2; IL-1RP2; IL-1 epsilon; IL-1F9; IL-1H1??[Similar Products]
UniProt Entry Name
IL36G_HUMAN
NCBI Summary for IL36G
The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
UniProt Comments for IL36G
Il1f9: Function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2. Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response. Belongs to the IL-1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytokine
Chromosomal Location of Human Ortholog: 2q12-q21
Cellular Component: extracellular region; extracellular space
Molecular Function: cytokine activity; interleukin-1 receptor binding
Biological Process: cell-cell signaling; cytokine and chemokine mediated signaling pathway; inflammatory response; innate immune response
Research Articles on IL36G
1. IL36G was identified as strong regulators of skin pathology in both lesional and non-lesional skin samples.
Precautions
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Disclaimer
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