Mouse Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; mitochondrial (DLAT) ELISA kit; DLTA; PDC-E2; PDCE2; 70 kDa mitochondrial autoantigen of primary biliary cirrhosis; E2 component of pyruvate dehydrogenase complex; M2 antigen complex 70 kDa subunit; dihydrolipoamide S-acetyltransferase

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of DLAT elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9325874 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the dihydrolipoamide S-acetyltransferase (DLAT) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing DLAT. The ELISA analytical biochemical technique of the MBS9325874 kit is based on DLAT antibody-DLAT antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect DLAT antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, DLAT. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

67,942 Da

dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)

dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; PDCE2; pyruvate dehydrogenase complex component E2; dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

PDC-E2; PDCE2??[Similar Products]

ODP2_MOUSE

DLAT: the E2 component of the pyruvate dehydrogenase complex (PDHC) that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. Contains two lipoyl-binding domains. The PDHC plays a major role in controlling the balance between lipid and glucose oxidation depending on substrate availability. The activity of the PDHC is tightly regulated by phosphorylation of the E1 components by the PDHKs. The pyruvate dehydrogenase (PDH) holoenzyme is a multi-enzyme complex (PDHC) that contains 20-30 copies of pyruvate decarboxylase tetramers (2 alpha:2 beta)(E1), 60 copies of dihydrolipoamide acetyltransferase (E2), six homo-dimers of dihydrolipoamide dehydrogenase (E3), plus E3 binding proteins. PDHKs are recruited to the PDHC by binding to a lipoyl group covalently attached to K174 of the inner lipoyl domain of the E2 component.

Protein type: Mitochondrial; EC 2.3.1.12; Carbohydrate Metabolism - pyruvate; Transferase; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis

Cellular Component: mitochondrion; pyruvate dehydrogenase complex; mitochondrial pyruvate dehydrogenase complex; myelin sheath

Molecular Function: transferase activity; dihydrolipoyllysine-residue acetyltransferase activity; transferase activity, transferring acyl groups

Biological Process: acetyl-CoA biosynthetic process from pyruvate; metabolic process; tricarboxylic acid cycle; carbohydrate metabolic process; glucose metabolic process; pyruvate metabolic process

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