Mouse Protoheme IX farnesyltransferase; mitochondrial (COX10) ELISA kit; cytochrome c oxidase assembly protein; cytochrome c oxidase subunit X; heme A: farnesyltransferase; heme A:farnesyltransferase; COX10 homolog; cytochrome c oxidase assembly protein; heme A: farnesyltransferase (yeast)

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of COX10 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9316775 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing COX10. The ELISA analytical biochemical technique of the MBS9316775 kit is based on COX10 antibody-COX10 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect COX10 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, COX10. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

48,884 Da

cytochrome c oxidase assembly protein 10

protoheme IX farnesyltransferase, mitochondrial; heme O synthase; COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase

Protoheme IX farnesyltransferase, mitochondrial

COX10_MOUSE

COX10: Converts protoheme IX and farnesyl diphosphate to heme O. Defects in COX10 are a cause of mitochondrial complex IV deficiency (MT-C4D); also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome. Defects in COX10 are a cause of Leigh syndrome (LS). LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions. Belongs to the UbiA prenyltransferase family.

Protein type: Membrane protein, integral; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 2.5.1.-; Transferase; Energy Metabolism - oxidative phosphorylation; Membrane protein, multi-pass

Cellular Component: mitochondrion; membrane; mitochondrial membrane; integral to membrane

Molecular Function: transferase activity; cytochrome-c oxidase activity; farnesyltranstransferase activity; protein geranylgeranyltransferase activity; protoheme IX farnesyltransferase activity; 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity; trans-pentaprenyltranstransferase activity; (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity; 4-hydroxybenzoate octaprenyltransferase activity; protein prenyltransferase activity; prenyltransferase activity

Biological Process: mitochondrion organization and biogenesis; mitochondrial fission; protein farnesylation; heme o biosynthetic process; respiratory chain complex IV assembly; cellular respiration; cytochrome complex assembly; aerobic respiration; heme a biosynthetic process; heme biosynthetic process

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