EC 1.2.1.3; Aldehyde dehydrogenase (NAD(+))

For Research Use Only. Not for use in diagnostic procedures.

Shipped and store at 4 degree C for 6 months.

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Small volumes of Aldh3a2 assay kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Background/Introduction: In mammals, ethanol is metabolized mainly in the liver by alcohol dehydrogenase (ADH), which oxidizes ethanol to acetaldehyde. Acetaldehyde, a toxic metabolite responsible for the miserable effects of hangovers, is further oxidized to acetate by aldehyde dehydrogenase (ALDH). ALDH belongs to a large family of aldehyde dehydrogenases that can be found in many tissues of the body, but are at the highest concentrations in the liver. In this assay, acetaldehyde is oxidized by ALDH generating NADH which then reduces a colorless probe to a colored product with strong absorbance at 340 nm. The intensity of the color formed is increased in the presence of increased ALDH activity.

Functional Assay

54,082 Da[Similar Products]

aldehyde dehydrogenase 3 family, member A2

fatty aldehyde dehydrogenase

Fatty aldehyde dehydrogenase

Aldh4; msALDH??[Similar Products]

AL3A2_RAT

ALDH3A2: Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. Defects in ALDH3A2 are the cause of Sjoegren-Larsson syndrome (SLS). SLS is an autosomal recessive neurocutaneous disorder characterized by a combination of severe mental retardation, spastic di- or tetraplegia and congenital ichthyosis (increased keratinization). Ichthyosis is usually evident at birth, neurologic symptoms appear in the first or second year of life. Most patients have an IQ of less than 60. Additional clinical features include glistening white spots on the retina, seizures, short stature and speech defects. Belongs to the aldehyde dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Membrane protein, integral; Amino Acid Metabolism - lysine degradation; Carbohydrate Metabolism - butanoate; Other Amino Acids Metabolism - beta-alanine; Amino Acid Metabolism - tryptophan; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Lipid Metabolism - glycerolipid; Carbohydrate Metabolism - ascorbate and aldarate; Secondary Metabolites Metabolism - limonene and pinene degradation; Carbohydrate Metabolism - pyruvate; Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 1.2.1.3; Amino Acid Metabolism - histidine; Amino Acid Metabolism - arginine and proline; Carbohydrate Metabolism - propanoate; Lipid Metabolism - fatty acid

Cellular Component: cytosol; endoplasmic reticulum; integral to membrane; intracellular membrane-bound organelle; mitochondrial inner membrane; mitochondrion; nucleus; peroxisome

Molecular Function: 3-chloroallyl aldehyde dehydrogenase activity; aldehyde dehydrogenase (NAD) activity; aldehyde dehydrogenase [NAD(P)+] activity; long-chain-alcohol oxidase activity; long-chain-aldehyde dehydrogenase activity

Biological Process: aldehyde metabolic process; central nervous system development; epidermis development; formaldehyde metabolic process; peripheral nervous system development; phytol metabolic process; response to reactive oxygen species; sesquiterpenoid metabolic process

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