AIK; ARK1; AURA; BTAK; STK6; STK7; STK15; AURORA2; MGC34538; AURKA

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG1

4G10

Mouse

Ascitic fluid containing 0.03% sodium azide.

Small volumes of anti-AURKA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Entrez Summary: Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment.Tissue specificity: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.

Western Blot (WB), Immunohistochemistry (IHC)

Western blot analysis using AURKA mouse mAb against HEK293 (1), Sw620 (2), MCF-7 (3), Jurkat (4), Hela (5), HepG2 (6), Cos7 (7) and PC-12 (8) cell lysate.

Immunohistochemical analysis of paraffin-embedded ovarian cancer (left) and lung cancer (right) using AURKA mouse mAb with DAB staining.

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aurora kinase A

aurora kinase A

Aurora kinase A

AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6; ARK-1; Aurora-related kinase 1; hARK1??[Similar Products]

The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

AurA: a member of the AUR family of kinases. A cell cycle-regulated serine/threonine protein kinase that is overexpressed in many tumor cell lines. Regulated by phosphorylation-dependent proteasomal degradation. Localized to mitotic centrosomes and spindle microtubules and is required for centrosome maturation. Loss of Aurora A leads to defective mitotic spindles and gross errors in chromosome segregation. Required for centrosome duplication and chromosome segregation. Overexpression in culture drives transformation and aneuploidy, and negatively regulates p53. Amplified or overexpressed in many tumors or cell lines. Found as a skin tumor susceptibility gene in mouse, and a human SNP in a degradation domain is weakly cancer-associated and undergoes allele-specific amplification. Inhibitors: VX-680, ZM447439, Hesperadin, SNS-595.

Protein type: AUR family; EC 2.7.11.1; Kinase, protein; Oncoprotein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 20q13.2

Cellular Component: centrosome; condensed nuclear chromosome, pericentric region; cytosol; microtubule cytoskeleton; midbody; nucleoplasm; nucleus; perinuclear region of cytoplasm; spindle; spindle microtubule; spindle midzone; spindle pole centrosome

Molecular Function: histone serine kinase activity; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity

Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; G2/M transition of mitotic cell cycle; mitosis; mitotic spindle organization and biogenesis; negative regulation of protein binding; positive regulation of mitosis; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of centrosome cycle; regulation of cytokinesis; regulation of protein stability; response to wounding; spindle organization and biogenesis

Disease: Colorectal Cancer

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