Full Product Name
ABCD4 Antibody
Product Synonym Names
ATP-binding cassette sub-family D member 4; Peroxisomal membrane protein 69; PMP69; Peroxisomal membrane protein 1-like; PXMP1-L; P70R
Product Gene Name
anti-ABCD4 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O14678
Species Reactivity
Human, Mouse
Specificity
ABCD4 Antibody detects endogenous levels of ABCD4.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human ABCD4.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-ABCD4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ABCD4 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-ABCD4 antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:10000
NCBI/Uniprot data below describe general gene information for ABCD4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005041.1
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NCBI GenBank Nucleotide #
NM_005050.3
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UniProt Primary Accession #
O14678
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UniProt Secondary Accession #
Q6IAQ0; Q96E75; A8K5L7[Other Products]
UniProt Related Accession #
O14678[Other Products]
NCBI Official Full Name
ATP-binding cassette sub-family D member 4 isoform a
NCBI Official Synonym Full Names
ATP binding cassette subfamily D member 4
NCBI Official Symbol
ABCD4??[Similar Products]
NCBI Official Synonym Symbols
P70R; P79R; ABC41; MAHCJ; PMP69; PXMP1L; EST352188
??[Similar Products]
NCBI Protein Information
ATP-binding cassette sub-family D member 4
UniProt Protein Name
ATP-binding cassette sub-family D member 4
UniProt Synonym Protein Names
PMP70-related protein; P70R; Peroxisomal membrane protein 1-like; PXMP1-L; Peroxisomal membrane protein 69; PMP69
Protein Family
ATP-binding cassette sub-family
UniProt Gene Name
ABCD4??[Similar Products]
UniProt Synonym Gene Names
PXMP1L; P70R; PXMP1-L; PMP69??[Similar Products]
NCBI Summary for ABCD4
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown. However, it is speculated that it may function as a heterodimer for another peroxisomal ABC transporter and, therefore, may modify the adrenoleukodystrophy phenotype. It may also play a role in the process of peroxisome biogenesis. Alternative splicing results in several protein-coding and non-protein-coding variants. [provided by RefSeq, Jul 2017]
UniProt Comments for ABCD4
May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm.
Research Articles on ABCD4
1. Data suggest that ABCD4 lysosomal targeting depends on co-expression of and interaction with LMBRD1; mutations in LMBRD1 and ABCD4 that result in cobalamin metabolism disorders cblF and cblJ (or mutations in ATPase domain) disrupt interactions between LMBRD1 and ABCD4. (LMBRD1 = nuclear export signal-interacting protein; ABCD4 = ATP-binding cassette, sub-family D (ALD), member 4)
Precautions
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Disclaimer
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