Product Name
RET, cDNA Clone
Full Product Name
RET cDNA Clone
Product Gene Name
RET cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggcgaagg cgacgtccgg tgccgcgggg ctgcgtctgc tgttgctgct gctgctgccg ctgctaggca aagtggcatt gggcctctac ttctcgaggg atgcttactg ggagaagctg tatgtggacc aggcggccgg cacgcccttg ctgtacgtcc atgccctgcg ggacgcccct gaggaggtgc ccagcttccg cctgggccag catctctacg gcacgtaccg cacacggctg catgagaaca actggatctg catccaggag gacaccggcc tcctctacct taaccggagc ctggaccata gctcctggga gaagctcagt gtccgcaacc gcggctttcc cctgctcacc gtctacctca aggtcttcct gtcacccaca tcccttcgtg agggcgagtg ccagtggcca ggctgtgccc gcgtatactt ctccttcttc aacacctcct ttccagcctg cagctccctc aagccccggg agctctgctt cccagagaca aggccctcct tccgcattcg ggagaaccga cccccaggca ccttccacca gttccgcctg ctgcctgtgc agttcttgtg ccccaacatc agcgtggcct acaggctcct ggagggtgag ggtctgccct tccgctgcgc cccggacagc ctggaggtga gcacgcgctg ggccctggac cgcgagcagc gggagaagta cgagctggtg gccgtgtgca ccgtgcacgc cggcgcgcgc gaggaggtgg tgatggtgcc cttcccggtg accgtgtacg acgaggacga ctcggcgccc accttccccg cgggcgtcga caccgccagc gccgtggtgg agttcaagcg gaaggaggac accgtggtgg ccacgctgcg tgtcttcgat gcagacgtgg tacctgcatc aggggagctg gtgaggcggt acacaagcac gctgctcccc ggggacacct gggcccagca gaccttccgg gtggaacact ggcccaacga gacctcggtc caggccaacg gcagcttcgt gcgggcgacc gtacatgact ataggctggt tctcaaccgg aacctctcca tctcggagaa ccgcaccatg cagctggcgg tgctggtcaa tgactcagac ttccagggcc caggagcggg cgtcctcttg ctccacttca acgtgtcggt gctgccggtc agcctgcacc tgcccagtac ctactccctc tccgtgagca ggagggctcg ccgatttgcc cagatcggga aagtctgtgt ggaaaactgc ctggcagatc tcacagggga tgcagtatct ggccgagatg aagctcgttc atcgggactt ggcagccaga aacatcctgg tagctga
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of RET cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for RET. It may not necessarily be applicable to this product.
NCBI Accession #
BC003072
[Other Products]
UniProt Secondary Accession #
Q15250; Q9BTB0; Q9H4A2; A8K6Z2[Other Products]
UniProt Related Accession #
P07949[Other Products]
Molecular Weight
119,847 Da
NCBI Official Full Name
Homo sapiens ret proto-oncogene, mRNA
NCBI Official Synonym Full Names
ret proto-oncogene
NCBI Official Symbol
RET??[Similar Products]
NCBI Official Synonym Symbols
PTC; MTC1; HSCR1; MEN2A; MEN2B; RET51; CDHF12; CDHR16; RET-ELE1
??[Similar Products]
NCBI Protein Information
proto-oncogene tyrosine-protein kinase receptor Ret
UniProt Protein Name
Proto-oncogene tyrosine-protein kinase receptor Ret
UniProt Synonym Protein Names
Cadherin family member 12; Proto-oncogene c-Ret
UniProt Gene Name
RET??[Similar Products]
UniProt Synonym Gene Names
CDHF12; CDHR16; PTC; RET51??[Similar Products]
UniProt Entry Name
RET_HUMAN
NCBI Summary for RET
This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their
biological validity has not been confirmed. [provided by RefSeq, Jul 2008]
UniProt Comments for RET
Ret: a proto-oncogenic receptor tyrosine kinase. Receptor for glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin and artemin. Part of a multicompetent receptor complex with other membrane-bound ligand-binding GDNF family receptors (aGFRs). Required for development of the kidney and neural crest-derived cell types. Three alternatively spliced isoforms have been described.
Protein type: Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Kinase, protein; Membrane protein, integral; TK group; Ret family
Chromosomal Location of Human Ortholog: 10q11.2
Cellular Component: cytoplasm; endosome membrane; integral to plasma membrane; intracellular membrane-bound organelle; plasma membrane; receptor complex
Molecular Function: calcium ion binding; protein binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; receptor activity
Biological Process: MAPKKK cascade; membrane protein proteolysis; neuron adhesion; positive regulation of cell adhesion mediated by integrin; positive regulation of cell migration; positive regulation of transcription, DNA-dependent; posterior midgut development; protein amino acid phosphorylation; regulation of cell adhesion; response to pain; signal transduction
Disease: Hirschsprung Disease, Susceptibility To, 1; Multiple Endocrine Neoplasia, Type Iia; Multiple Endocrine Neoplasia, Type Iib; Thyroid Carcinoma, Familial Medullary; Thyroid Carcinoma, Papillary
Research Articles on RET
1. the RET p.S891A mutation combined with OSMR p.G513D may underlie a novel phenotype manifesting as familial medullary thyroid carcinoma and cutaneous amyloidosis
Precautions
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Disclaimer
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