Product Name
15 kDa selenoprotein (SEP15), Recombinant Protein
Popular Item
Full Product Name
Recombinant Human 15 kDa selenoprotein (SEP15)
Product Gene Name
SEP15 recombinant protein
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
29-162aa, Full Length of Mature Protein
Sequence
FGAEFSSEAC RELGFSSNLL CSSCDLLGQF NLLQLDPDCR GCCQEEAQFE TKKLYAGAIL EVCGUKLGRF PQVQAFVRSD KPKLFRGLQI KYVRGSDPVL KLLDDNGNIA EELSILKWNT DSVEEFLSEK LERI
3D Structure
ModBase 3D Structure for O60613
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of SEP15 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for SEP15. It may not necessarily be applicable to this product.
NCBI Accession #
NP_004252.2
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NCBI GenBank Nucleotide #
NM_004261.4
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UniProt Primary Accession #
O60613
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UniProt Secondary Accession #
Q4GZG7; Q8WU00; Q9BS64; Q9GZW0; Q9NR01[Other Products]
UniProt Related Accession #
O60613[Other Products]
Molecular Weight
13,219 Da
NCBI Official Full Name
selenoprotein F isoform 1
NCBI Official Synonym Full Names
selenoprotein F
NCBI Official Symbol
SELENOF??[Similar Products]
NCBI Official Synonym Symbols
SEP15
??[Similar Products]
NCBI Protein Information
selenoprotein F
UniProt Protein Name
Selenoprotein F
UniProt Synonym Protein Names
15 kDa selenoprotein
UniProt Gene Name
SELENOF??[Similar Products]
NCBI Summary for SEP15
The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. It has also been suggested to have a role in cancer etiology. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2016]
UniProt Comments for SEP15
May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to the quality control of protein folding in the endoplasmic reticulum ().
Research Articles on SEP15
1. The allelic and genotypic frequencies did not differ between rapid and nonrapid progressors; however, the presence of the AA genotype of the rs5859 polymorphism was associated with a shorter time of progression to AIDS compared with GG homozygotes (hazard ratio = 3.62, 95% CI = 1.55-8.43, p = 0.003).
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
