Product Name
ALDH3A2, cDNA Clone
Popular Item
Full Product Name
ALDH3A2 cDNA Clone
Product Gene Name
ALDH3A2 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggagctcg aagtccggcg ggtccgacag gcgttcctgt ccggccggtc gcgacctctg cggtttcggc tgcagcagct ggaggccctg cggaggatgg tgcaggagcg cgagaaggat atcctgacgg ccatcgccgc cgacctgtgc aagagtgaat tcaatgtgta cagtcaggaa gtcattactg tccttgggga aattgatttt atgcttgaga atcttcctga atgggttact gctaaaccag ttaagaagaa cgtgctcacc atgctggatg aggcctatat tcagccacag cctctgggag tggtgctgat aatcggagct tggaattacc ccttcgttct caccattcag ccactgatag gagccatcgc tgcaggaaat gctgtgatta taaagccttc tgaactgagt gaaaatacag ccaagatctt ggcaaagctt ctccctcagt atttagacca ggatctctat attgttatta atggtggtgt tgaggaaacc acggagctcc tgaagcagcg atttgaccac attttctata cgggaaacac tgcggttggc aaaattgtca tggaagctgc tgccaagcat ctgacccctg tgactcttga actgggaggg aaaagtccat gttatattga taaagattgt gacctggaca ttgtttgcag acgcataacc tggggaaaat acatgaattg tggccaaacc tgcattgcac ccgactatat tctctgtgaa gcatccctcc aaaatcaaat tgtatggaag attaaggaaa cagtgaagga attttatgga gaaaatataa aagagtctcc tgattatgaa aggatcatca atcttcgtca ttttaagagg atactaagtt tgcttgaagg acaaaagata gcttttggtg gggagactga tgaggccaca cgctacatag ccccaacagt acttaccgat gttgatccta aaaccaaggt gatgcaagaa gaaatttttg gaccaattct tccaatagtg cctgtgaaaa atgtagatga ggccataaat ttcataaatg aacgtgaaaa gcctctggct ctttatgtat tttcgcataa ccataagctc atcaaacgga tgattgatga gacatccagt ggaggtgtca caggcaatga cgtcattatg cacttcacgc tcaactcttt cccatttgga ggagtgggtt ccagtgggat gggagcttat cacggaaaac atagttttga tactttttct catcagcgtc cctgtttatt aaaaagttta aagagagaag gtgctaacaa actcagatat cctcccaaca gccagtcaaa ggtggattgg ggaaaatttt ttctcttgaa acggttcaac aaagaaaaac tcggtctcct gttgctcact ttcctgggta ttgtagccgc tgtgcttgtc aagaaatacc aagctgtgct gaggagaaag gccctgttga tttttctggt agttcacaga ctgcgttggt ccagtaagca gagatga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ALDH3A2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ALDH3A2. It may not necessarily be applicable to this product.
NCBI Accession #
BC002430
[Other Products]
UniProt Secondary Accession #
Q6I9T3; Q93011; Q96J37[Other Products]
UniProt Related Accession #
P51648[Other Products]
Molecular Weight
57,669 Da
NCBI Official Full Name
Homo sapiens aldehyde dehydrogenase 3 family, member A2, mRNA
NCBI Official Synonym Full Names
aldehyde dehydrogenase 3 family member A2
NCBI Official Symbol
ALDH3A2??[Similar Products]
NCBI Official Synonym Symbols
SLS; FALDH; ALDH10
??[Similar Products]
NCBI Protein Information
fatty aldehyde dehydrogenase
UniProt Protein Name
Fatty aldehyde dehydrogenase
UniProt Synonym Protein Names
Aldehyde dehydrogenase 10; Aldehyde dehydrogenase family 3 member A2; Microsomal aldehyde dehydrogenase
Protein Family
Fatty aldehyde dehydrogenase
UniProt Gene Name
ALDH3A2??[Similar Products]
UniProt Synonym Gene Names
ALDH10; FALDH??[Similar Products]
UniProt Entry Name
AL3A2_HUMAN
NCBI Summary for ALDH3A2
Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ALDH3A2
ALDH3A2: Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. Defects in ALDH3A2 are the cause of Sjoegren-Larsson syndrome (SLS). SLS is an autosomal recessive neurocutaneous disorder characterized by a combination of severe mental retardation, spastic di- or tetraplegia and congenital ichthyosis (increased keratinization). Ichthyosis is usually evident at birth, neurologic symptoms appear in the first or second year of life. Most patients have an IQ of less than 60. Additional clinical features include glistening white spots on the retina, seizures, short stature and speech defects. Belongs to the aldehyde dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Amino Acid Metabolism - lysine degradation; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Mitochondrial; Secondary Metabolites Metabolism - limonene and pinene degradation; Other Amino Acids Metabolism - beta-alanine; Amino Acid Metabolism - histidine; Oxidoreductase; EC 1.2.1.3; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Amino Acid Metabolism - arginine and proline; Lipid Metabolism - fatty acid; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; Lipid Metabolism - glycerolipid; Membrane protein, integral; Amino Acid Metabolism - tryptophan
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; peroxisomal membrane
Molecular Function: 3-chloroallyl aldehyde dehydrogenase activity; aldehyde dehydrogenase (NAD) activity; long-chain-alcohol oxidase activity
Biological Process: aldehyde metabolic process; central nervous system development; epidermis development; fatty acid alpha-oxidation; peripheral nervous system development; phytol metabolic process; sphingolipid biosynthetic process
Disease: Sjogren-larsson Syndrome
Research Articles on ALDH3A2
1. The gatekeeper helix domain is important for directing the substrate specificity of FALDH towards long-chain fatty aldehydes.
Precautions
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Disclaimer
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