Product Name
PNPLA3, cDNA Clone
Full Product Name
PNPLA3 cDNA Clone
Product Gene Name
PNPLA3 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgtacgacg cagagcgcgg ctggagcttg tccttcgcgg gctgcggctt cctgggcttc taccacgtcg gggcgacccg ctgcctgagc gagcacgccc cgcacctcct ccgcgacgcg cgcatgttgt tcggcgcttc ggccggggcg ttgcactgcg tcggcgtcct ctccggtatc ccgctggagc agactctgca ggtcctctca gatcttgtgc ggaaggccag gagtcggaac attggcatct tccatccatc cttcaactta agcaagttcc tccgacaggg tctcggcaaa tgcctcccgg ccaatgtcca ccagctcatc tccggcaaaa taggcatctc tcttaccaga gtgtctgatg gggaaaacgt tctggtgtct gactttcggt ccaaagacga agtcgtggat gccttggtat gttcctgctt catgcctttc tacagtggcc ttatccctcc ttccttcaga ggcgtgcgat atgtggatgg aggagtgagt gacaacgtac ccttcattga tgccaaaaca accatcaccg tgtccccctt ctatggggag tacgacatct gccctaaagt caagtccacg aactttcttc atgtggacat caccaagctc agtctacgcc tctgcacagg gaacctctac cttctctcga gagcttttgt ccccccggat ctcaaggtgc tgggagagat atgccttcga ggatatttgg atgcattcag gttcttggaa gagaagggca tctgcaacag gccccagcca ggcctgaagt catcctcaga agggatggat cctgaggtcg ccatgcccag ctgggcaaac atgagtctgg attcttcccc ggagtcggct gccttggctg tgaggctgga gggagatgag ctgctagacc acctgcgtct cagcatcctg ccctgggatg agagcatcct ggacaccctc tcgcccaggc tcgctacagc actgagtgaa gaaatgaaag acaaaggtgg atacatgagc aagatttgca acttgctacc cattaggata atgtcttatg taatgctgcc ctgtaccctg cctgtggaat ctgccattgc gattgtccag agactggtga catggcttcc agatatgccc gacgatgtcc tgtggttgca gtgggtgacc tcacaggtgt tcactcgagt gctgatgtgt ctgctccccg cctccaggtc ccaaatgcca gtgagcagcc aacaggcctc cccatgcaca cctgagcagg actggccctg ctggactccc tgctcccccg agggctgtcc agcagagacc aaagcagagg ccaccccgcg gtccatcctc aggtccagcc tgaacttctt cttgggcaat aaagtacctg ctggtgctga ggggctctcc acctttccca gtttttcact agagaagagt ctgtga
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of PNPLA3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for PNPLA3. It may not necessarily be applicable to this product.
NCBI Accession #
BC065195
[Other Products]
UniProt Secondary Accession #
Q6P1A1; Q96CB4; B0QYI0; B2RCL3; B3KW00[Other Products]
UniProt Related Accession #
Q9NST1[Other Products]
Molecular Weight
52,485 Da
NCBI Official Full Name
Homo sapiens patatin-like phospholipase domain containing 3, mRNA
NCBI Official Synonym Full Names
patatin like phospholipase domain containing 3
NCBI Official Symbol
PNPLA3??[Similar Products]
NCBI Official Synonym Symbols
ADPN; C22orf20; iPLA(2)epsilon
??[Similar Products]
NCBI Protein Information
patatin-like phospholipase domain-containing protein 3
UniProt Protein Name
Patatin-like phospholipase domain-containing protein 3
UniProt Synonym Protein Names
Acylglycerol O-acyltransferase (EC:2.3.1.-); Adiponutrin; Calcium-independent phospholipase A2-epsilon; iPLA2-epsilon
Protein Family
Patatin-like phospholipase domain-containing protein
UniProt Gene Name
PNPLA3??[Similar Products]
UniProt Synonym Gene Names
ADPN; C22orf20; iPLA2-epsilon??[Similar Products]
UniProt Entry Name
PLPL3_HUMAN
NCBI Summary for PNPLA3
The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided by RefSeq, Jul 2008]
UniProt Comments for PNPLA3
PNPLA3: Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities. Genetic variations in PNPLA3 are a cause of susceptibility to non-alcoholic fatty liver disease type 1 (NAFLD1). A condition characterized by an accumulation of excess triglyceride in the liver, a condition known as hepatic steatosis (or fatty liver), which is associated with adverse metabolic consequences, including insulin resistance and dyslipidemia. In a subset of individuals, hepatic steatosis promotes an inflammatory response in the liver, referred to as steatohepatitis, which can progress to cirrhosis and liver cancer. NAFLD is the most common form of liver disease in Western countries. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Lipid Metabolism - glycerolipid; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - phenylalanine; Membrane protein, integral; Transferase; EC 3.1.1.3; Secondary Metabolites Metabolism - limonene and pinene degradation; Lipid Metabolism - glycerophospholipid; Phospholipase
Chromosomal Location of Human Ortholog: 22q13.31
Cellular Component: cytoplasm; endoplasmic reticulum membrane; lipid particle; membrane
Molecular Function: acylglycerol O-acyltransferase activity; diolein transacylation activity; lipoprotein lipase activity; mono-olein transacylation activity; phospholipase A2 activity; triacylglycerol lipase activity
Biological Process: lipid homeostasis; triacylglycerol biosynthetic process; triacylglycerol catabolic process
Research Articles on PNPLA3
1. The rs2629751 genotype may be an important predictor of posttransplant outcome in HCV-infected patients.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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