For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Affinity Purified

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-PNPLA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This is a rabbit polyclonal antibody against PNPLA3. It was validated on Western Blot and immunohistochemistry

Target Description: PNPLA3 is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes.The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes.

Polyclonal; Signal Proteins; Lymphocyte Signaling; Membrane Protein; Drugs and Drug Metabolism; Developmental Biology; Immunohistochemistry; Receptors;

Immunohistochemistry (IHC), Western Blot (WB)

Human Heart

Host: Rabbit
Target Name: PNPLA3
Sample Tissue: Human Hela Whole Cell
Antibody Dilution: 1ug/ml

WB Suggested Anti-PNPLA3 Antibody Titration: 1 ug/ml
Positive Control: Jurkat cell lysate

53kDa

patatin like phospholipase domain containing 3

1-acylglycerol-3-phosphate O-acyltransferase PNPLA3

Patatin-like phospholipase domain-containing protein 3

ADPN; C22orf20; iPLA2-epsilon??[Similar Products]

PLPL3_HUMAN

The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided by RefSeq, Jul 2008]

PNPLA3: Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities. Genetic variations in PNPLA3 are a cause of susceptibility to non-alcoholic fatty liver disease type 1 (NAFLD1). A condition characterized by an accumulation of excess triglyceride in the liver, a condition known as hepatic steatosis (or fatty liver), which is associated with adverse metabolic consequences, including insulin resistance and dyslipidemia. In a subset of individuals, hepatic steatosis promotes an inflammatory response in the liver, referred to as steatohepatitis, which can progress to cirrhosis and liver cancer. NAFLD is the most common form of liver disease in Western countries. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - glycerolipid; Transferase; Lipid Metabolism - glycerophospholipid; Secondary Metabolites Metabolism - limonene and pinene degradation; Phospholipase; Amino Acid Metabolism - tyrosine; Membrane protein, integral; EC 3.1.1.3; Amino Acid Metabolism - phenylalanine

Chromosomal Location of Human Ortholog: 22q13.31

Cellular Component: endoplasmic reticulum membrane; membrane; integral to membrane

Molecular Function: phospholipase A2 activity; triacylglycerol lipase activity; mono-olein transacylation activity; diolein transacylation activity

Biological Process: phospholipid metabolic process; glycerophospholipid biosynthetic process; triacylglycerol catabolic process; triacylglycerol biosynthetic process

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