Product Name
Acetylserotonin O-Methyltransferase (ASMT), Recombinant Protein
Full Product Name
Recombinant Human Acetylserotonin O-Methyltransferase
Product Synonym Names
ASMT Human; Acetylserotonin O-Methyltransferase Human Recombinant; HIOMT; HIOMTY; Acetylserotonin O-methyltransferase; Hydroxyindole O-methyltransferase; ASMT
Product Gene Name
ASMT recombinant protein
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MGSSHHH HHH SSGLVPRGSH MGSSEDQAYR LLNDYANGFM VSQVLFAACE LGVFDLLAEA PGPLDVAAVA AGVRASAHGT ELLLDICVSL KLLKVETRGG KAFYRNTELS SDYLTTVSPT SQCSMLKYMG RTSYRCWGHL ADAVREGRNQ YLETFGVPAE ELFTAIYRSE GERLQFMQAL QEVWSVNGRS VLTAFDLSVF PLMCDLGGDF FKDPLPEADL YILARVLHDW ADGKCSHLLE RIYHTCKPGG GILVIESLLD EDRRGPLLTQ LYSLNMLVQT EGQERTPTHY HMLLSSAGFR DFQFKKTGAI YDAILARK
3D Structure
ModBase 3D Structure for P46597
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Form/Format
The ASMT solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1M Urea and 10% glycerol.
Sterile Filtered clear solution.
Other Notes
Small volumes of ASMT recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ASMT recombinant protein
Description: ASMT Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 318 amino acids (1-298 a.a) and having a molecular mass of 35.3kDa.ASMT is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction: ASMT is a member of the methyltransferase superfamily. ASMT participates in melatonin biosynthesis. ASMT Expressed in brain, retina and pineal gland, ASMT utilities to catalyze the final reaction in the synthesis of melatonin, particularly the conversion of S-adenosyl-L-methionine and N-acetylserotonin to S-adenosyl-Lhomocysteine and melatonin.
Product Categories/Family for ASMT recombinant protein
ENZYMES; Enzymes; Transferase
NCBI/Uniprot data below describe general gene information for ASMT. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001164509.1
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NCBI GenBank Nucleotide #
NM_001171038.1
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UniProt Primary Accession #
P46597
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UniProt Secondary Accession #
Q16598; Q5JQ72; Q5JQ73; B2RC33[Other Products]
UniProt Related Accession #
P46597[Other Products]
Molecular Weight
41,661 Da
NCBI Official Full Name
acetylserotonin O-methyltransferase isoform 1
NCBI Official Synonym Full Names
acetylserotonin O-methyltransferase
NCBI Official Symbol
ASMT??[Similar Products]
NCBI Official Synonym Symbols
ASMTY; HIOMT; HIOMTY
??[Similar Products]
NCBI Protein Information
acetylserotonin O-methyltransferase; acetylserotonin N-methyltransferase; acetylserotonin methyltransferase (Y chromosome); hydroxyindole O-methyltransferase
UniProt Protein Name
Acetylserotonin O-methyltransferase
UniProt Synonym Protein Names
Hydroxyindole O-methyltransferase; HIOMT
Protein Family
Acetylserotonin O-methyltransferase
UniProt Gene Name
ASMT??[Similar Products]
UniProt Synonym Gene Names
HIOMT??[Similar Products]
UniProt Entry Name
ASMT_HUMAN
NCBI Summary for ASMT
This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2010]
UniProt Comments for ASMT
ASMT: Produces melatonin (N-acetyl-5-methoxytryptamine) from N-acetylserotonin. Belongs to the methyltransferase superfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Methyltransferase; EC 2.1.1.4; Amino Acid Metabolism - tryptophan
Chromosomal Location of Human Ortholog: Xp22.3 or Yp11.3
Cellular Component: cytosol
Molecular Function: identical protein binding; protein homodimerization activity; O-methyltransferase activity; acetylserotonin O-methyltransferase activity
Biological Process: methylation; melatonin biosynthetic process; translation; indolalkylamine biosynthetic process
Research Articles on ASMT
1. These data suggest a relationship between decreased mRNA and protein expression levels of ASMT gene and cognitive impairment.
Precautions
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Disclaimer
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