Patatin-like phospholipase domain-containing protein 3; Acylglycerol O-acyltransferase; 231-; Adiponutrin; Calcium-independent phospholipase A2-epsilon; iPLA2-epsilon; PNPLA3; ADPN; C22orf20

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This PNPLA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-137 amino acids from the N-terminal region of human PNPLA3.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.33 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-PNPLA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The protein encoded by this gene is a triacylglycerol
lipase that mediates triacylglycerol hydrolysis in adipocytes. The
encoded protein, which appears to be membrane bound, may be
involved in the balance of energy usage/storage in adipocytes.

Cardiovascular; Metabolism; Signal Transduction

Western Blot (WB), ELISA (EIA)

WB~~1:1000

PNPLA3 Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the PNPLA3 antibody detected the PNPLA3 protein (arrow).

52865

patatin-like phospholipase domain containing 3

patatin-like phospholipase domain-containing protein 3

Patatin-like phospholipase domain-containing protein 3

ADPN; C22orf20; iPLA2-epsilon??[Similar Products]

PLPL3_HUMAN

The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided by RefSeq, Jul 2008]

PNPLA3: Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities. Genetic variations in PNPLA3 are a cause of susceptibility to non-alcoholic fatty liver disease type 1 (NAFLD1). A condition characterized by an accumulation of excess triglyceride in the liver, a condition known as hepatic steatosis (or fatty liver), which is associated with adverse metabolic consequences, including insulin resistance and dyslipidemia. In a subset of individuals, hepatic steatosis promotes an inflammatory response in the liver, referred to as steatohepatitis, which can progress to cirrhosis and liver cancer. NAFLD is the most common form of liver disease in Western countries. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.1.3; Secondary Metabolites Metabolism - limonene and pinene degradation; Phospholipase; Amino Acid Metabolism - phenylalanine; Transferase; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Membrane protein, integral; Amino Acid Metabolism - tyrosine

Chromosomal Location of Human Ortholog: 22q13.31

Cellular Component: endoplasmic reticulum membrane; membrane; integral to membrane

Molecular Function: phospholipase A2 activity; triacylglycerol lipase activity; mono-olein transacylation activity; diolein transacylation activity

Biological Process: phospholipid metabolic process; triacylglycerol catabolic process; glycerophospholipid biosynthetic process; triacylglycerol biosynthetic process

Santoro, N., et al. Hepatology 52(4):1281-1290(2010)
Valenti, L., et al. Hepatology 52(4):1274-1280(2010)
Rotman, Y., et al. Hepatology 52(3):894-903(2010)
Speliotes, E.K., et al. Hepatology 52(3):904-912(2010)
Pare, G., et al. PLoS Genet. 6 (6), E1000981 (2010) :

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.