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PRG4, Polyclonal Antibody

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產(chǎn)品名稱: PRG4, Polyclonal Antibody
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PRG4, Polyclonal Antibody


PRG4, Polyclonal Antibody  的詳細(xì)介紹
Product Name

PRG4, Polyclonal Antibody

Full Product Name

PRG4 Polyclonal Antibody

Product Synonym Names
CACP; HAPO; JCAP; MSF; SZP
Product Gene Name

anti-PRG4 antibody

[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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Immunogen Sequence
ERAIGPSQTH TIRIQYSPAR LAYQDKGVLH NEVKVSILWR GLPNVVTSAI SLPNIRKPDG YDYYAFSKDQ YYNIDVPSRT ARAITTRSGQ TLSKVWYNCP
OMIM
U70136 mRNA
3D Structure
ModBase 3D Structure for Q92954
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat
Purity/Purification
Affinity Purification
Immunogen
Recombinant protein of human PRG4
Immunogen Species
Human
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Cellular Location
Secreted
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Other Notes
Small volumes of anti-PRG4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for
anti-PRG4 antibody
The protein encoded by this gene is a large proteoglycan that is synthesized by chondrocytes located at the surface of articular cartilage and by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Alternative splicing results in multiple transcript variants.
Product Categories/Family for anti-PRG4 antibody
Polyclonal Antibodies
Applications Tested/Suitable for anti-PRG4 antibody
Western Blot (WB)
Application Notes for anti-PRG4 antibody
WB: 1:200 - 1:2000
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NCBI/Uniprot data below describe general gene information for PRG4. It may not necessarily be applicable to this product.
NCBI GI #
735997424
NCBI GeneID
10216
NCBI Accession #
NP_001121180.2 [Other Products]
NCBI GenBank Nucleotide #
NM_001127708.2 [Other Products]
UniProt Primary Accession #
Q92954 [Other Products]
UniProt Secondary Accession #
Q6DNC4; Q6DNC5; Q6ZMZ5; Q9BX49[Other Products]
UniProt Related Accession #
Q92954[Other Products]
Molecular Weight
102kDa/136kDa/141kDa/146kDa/151kDa
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NCBI Official Full Name
proteoglycan 4 isoform B preproprotein
NCBI Official Synonym Full Names
proteoglycan 4
NCBI Official Symbol
PRG4??[Similar Products]
NCBI Official Synonym Symbols
MSF; SZP; CACP; HAPO; JCAP
??[Similar Products]
NCBI Protein Information
proteoglycan 4
UniProt Protein Name
Proteoglycan 4
UniProt Synonym Protein Names
Lubricin; Megakaryocyte-stimulating factor; Superficial zone proteoglycan
Protein Family
Proteoglycan
UniProt Gene Name
PRG4??[Similar Products]
UniProt Synonym Gene Names
MSF; SZP??[Similar Products]
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NCBI Summary for PRG4
The protein encoded by this gene is a large proteoglycan that is synthesized by chondrocytes located at the surface of articular cartilage and by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
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UniProt Comments for PRG4
Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface.Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages.MiscellaneousDifferent forms varying in molecular weight have been observed. Such forms are possibly due to different levels of glycosylation and protein cleavage ().
Research Articles on PRG4
1. IL6 and PRG4 represent potential novel tissue biomarkers of disease severity and prognosis in conjunctival fibrosis after glaucoma surgery.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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