Patatin-like phospholipase domain-containing protein 3; Acylglycerol O-acyltransferase; 231-; Adiponutrin; Calcium-independent phospholipase A2-epsilon; iPLA2-epsilon; Pnpla3; Adpn

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This Mouse Pnpla3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 366-393 amino acids from the C-terminal region of mouse Pnpla3.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.47 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-Pnpla3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities (By similarity).

Cardiovascular; Metabolism; Signal Transduction

Western Blot (WB), ELISA (EIA)

WB~~1:1000

Mouse Pnpla3 Antibody (C-term) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the Pnpla3 antibody detected the Pnpla3 protein (arrow).

45772

patatin-like phospholipase domain containing 3

patatin-like phospholipase domain-containing protein 3

Patatin-like phospholipase domain-containing protein 3

Adpn; iPLA2-epsilon??[Similar Products]

PLPL3_MOUSE

PNPLA3: Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities. Genetic variations in PNPLA3 are a cause of susceptibility to non-alcoholic fatty liver disease type 1 (NAFLD1). A condition characterized by an accumulation of excess triglyceride in the liver, a condition known as hepatic steatosis (or fatty liver), which is associated with adverse metabolic consequences, including insulin resistance and dyslipidemia. In a subset of individuals, hepatic steatosis promotes an inflammatory response in the liver, referred to as steatohepatitis, which can progress to cirrhosis and liver cancer. NAFLD is the most common form of liver disease in Western countries. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secondary Metabolites Metabolism - limonene and pinene degradation; Lipid Metabolism - glycerolipid; Amino Acid Metabolism - tyrosine; Membrane protein, integral; EC 3.1.1.3; Transferase; Lipid Metabolism - glycerophospholipid; Phospholipase; Amino Acid Metabolism - phenylalanine

Cellular Component: membrane; integral to membrane

Molecular Function: phospholipase A2 activity; triacylglycerol lipase activity; glucosaminyl-phosphotidylinositol O-acyltransferase activity; S-malonyltransferase activity; S-acetyltransferase activity; O-octanoyltransferase activity; O-sinapoyltransferase activity; palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity; peptidyl-lysine N6-myristoyltransferase activity; azetidine-2-carboxylic acid acetyltransferase activity; Ras palmitoyltransferase activity; palmitoyltransferase activity; C-palmitoyltransferase activity; malonyltransferase activity; octanoyltransferase activity; O-succinyltransferase activity; hydrolase activity; sterol O-acyltransferase activity; O-acyltransferase activity; O-acetyltransferase activity; benzoyl acetate-CoA thiolase activity; transferase activity; sinapoyltransferase activity; S-acyltransferase activity; N-succinyltransferase activity; L-2-aminoadipate N-acetyltransferase activity; diolein transacylation activity; keto acid formate lyase activity; 3-hydroxybutyryl-CoA thiolase activity; acyl-CoA N-acyltransferase activity; peptidyl-lysine N6-palmitoyltransferase activity; dihydrolipoamide branched chain acyltransferase activity; succinyltransferase activity; C-acyltransferase activity; dihydrolipoamide S-acyltransferase activity; N-acetyltransferase activity; protein-cysteine S-acyltransferase activity; serine O-acyltransferase activity; O-palmitoyltransferase activity; 3-ketopimelyl-CoA thiolase activity; carnitine O-acyltransferase activity; S-succinyltransferase activity; N-acyltransferase activity; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity; N-palmitoyltransferase activity; acylglycerol O-acyltransferase activity; mono-olein transacylation activity; protein-cysteine S-myristoyltransferase activity; acetyltransferase activity; myristoyltransferase activity; transferase activity, transferring acyl groups

Biological Process: metabolic process; triacylglycerol catabolic process; triacylglycerol biosynthetic process; lipid metabolic process; lipid catabolic process

Chen, W., et al. Hepatology 52(3):1134-1142(2010)
Hoekstra, M., et al. J. Hepatol. 52(2):244-251(2010)
Kershaw, E.E., et al. Diabetes 55(1):148-157(2006)
Baulande, S., et al. J. Biol. Chem. 276(36):33336-33344(2001)

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.