Product Name
PNPLA3, Polyclonal Antibody
Full Product Name
PNPLA3 (Patatin-like Phospholipase Domain-containing Protein 3, Acylglycerol O-acyltransferase, Adiponutrin, Calcium-independent Phospholipase A2-epsilon, iPLA2-epsilon, ADPN, C22orf20, dJ796I17.1, FLJ22012)
Product Synonym Names
Anti -PNPLA3 (Patatin-like Phospholipase Domain-containing Protein 3, Acylglycerol O-acyltransferase, Adiponutrin, Calcium-independent Phospholipase A2-epsilon, iPLA2-epsilon, ADPN, C22orf20, dJ796I17.1, FLJ22012)
Product Gene Name
anti-PNPLA3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
MYDAERGWSL SFAGCGFLGF YHVGATRCLS EHAPHLLRDA RMLFGASAGA LHCVGVLSGI PLEQTLQVLS DLVRKARSRN IGIFHPSFNL SKFLRQGLGK CLPANVHQLI SGKIGISLTR VSDGENVLVS DFRSKDEVVD ALVCSCFMPF YSGLIPPSFR GVRYVDGGVS DNVPFIDAKT TITVSPFYGE YDICPKVKST NFLHVDITKL SLRLCTGNLY LLSRAFVPPD LKVLGEICLR GYLDAFRFLE EKGICNRPQP GLKSSSEGMD PEVAMPSWAN MSLDSSPESA ALAVRLEGDE LLDHLRLSIL PWDESILDTL SPRLATALSE EMKDKGGYMS KICNLLPIRI MSYVMLPCTL PVESAIAIVQ RLVTWLPDMP DDVLWLQWVT SQVFTRVLMC LLPASRSQMP VSSQQASPCT PEQDWPCWTP CSPEGCPAET KAEATPRSIL RSSLNFFLGN KVPAGAEGLS TFPSFSLEKS L
Chromosome Location
Chromosome: 22; NC_000022.10 (44319619..44343451). Location: 22q13.31
3D Structure
ModBase 3D Structure for Q9NST1
Specificity
Recognizes human PNPLA3.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Immunogen
Full length human PNPLA3, aa1-481 (AAH65195.1).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-PNPLA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PNPLA3 antibody
Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities.
Product Categories/Family for anti-PNPLA3 antibody
Antibodies; Abs to Obesity Proteins
Applications Tested/Suitable for anti-PNPLA3 antibody
Western Blot (WB)
Application Notes for anti-PNPLA3 antibody
Suitable for use in Western Blot.
NCBI/Uniprot data below describe general gene information for PNPLA3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_079501.2
[Other Products]
NCBI GenBank Nucleotide #
NM_025225.2
[Other Products]
UniProt Primary Accession #
Q9NST1
[Other Products]
UniProt Secondary Accession #
Q6P1A1; Q96CB4; B0QYI0; B2RCL3; B3KW00[Other Products]
UniProt Related Accession #
Q9NST1[Other Products]
Molecular Weight
52,865 Da[Similar Products]
NCBI Official Full Name
patatin-like phospholipase domain-containing protein 3
NCBI Official Synonym Full Names
patatin-like phospholipase domain containing 3
NCBI Official Symbol
PNPLA3??[Similar Products]
NCBI Official Synonym Symbols
ADPN; C22orf20; iPLA(2)epsilon
??[Similar Products]
NCBI Protein Information
patatin-like phospholipase domain-containing protein 3; adiponutrin; iPLA2epsilon; iPLA2-epsilon; acylglycerol O-acyltransferase; calcium-independent phospholipase A2-epsilon
UniProt Protein Name
Patatin-like phospholipase domain-containing protein 3
UniProt Synonym Protein Names
Acylglycerol O-acyltransferase (EC:2.3.1.-); Adiponutrin; Calcium-independent phospholipase A2-epsilon; iPLA2-epsilon
Protein Family
Patatin-like phospholipase domain-containing protein
UniProt Gene Name
PNPLA3??[Similar Products]
UniProt Synonym Gene Names
ADPN; C22orf20; iPLA2-epsilon??[Similar Products]
UniProt Entry Name
PLPL3_HUMAN
NCBI Summary for PNPLA3
The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided by RefSeq, Jul 2008]
UniProt Comments for PNPLA3
Function: Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities. Ref.7
Catalytic activity: Triacylglycerol + H2O = diacylglycerol + a carboxylate.
Pathway: Glycerolipid metabolism; triacylglycerol degradation.
Subcellular location: Membrane; Single-pass type II membrane protein Ref.7.
Induction: By changes in energy balance: down-regulated following very low-calorie diet, whereas refeeding elevates the mRNA level. Ref.8
Polymorphism: Polymorphic variation at position 148 influences insulin secretion levels and obesity. In obese subjects the body mass index and waist are higher in carriers of the Ile-148 allele. The Ile-148 carriers also display decreased insulin secretion in response to oral glucose tolerance test. Met-148 allele carriers are seemingly more insulin resistant at a lower body mass index.
Involvement in disease: Non-alcoholic fatty liver disease 1 (NAFLD1) [MIM:613282]: A condition characterized by accumulation of triglycerides in the liver. It is associated with adverse metabolic consequences, including insulin resistance and dyslipidemia. In a subset of individuals, hepatic steatosis promotes an inflammatory response in the liver, referred to as steatohepatitis, which can progress to cirrhosis and liver cancer. NAFLD is the most common form of liver disease in Western countries.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.10 Ref.11 Ref.13
Sequence similarities: Contains 1 patatin domain.
Research Articles on PNPLA3
1. In male PSC patients with severe disease with bile duct stenosis requiring intervention, the common I148M variant of the PNPLA3 gene is a risk factor for reduced survival.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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