Anti-PNPLA3 / Adiponutrin Antibody (Internal) IHC-plus; PNPLA3; ADPN; Acylglycerol O-acyltransferase; C22orf20; Adiponutrin; IPLA2epsilon; DJ796I17.1; IPLA(2)epsilon; IPLA2-epsilon; Human PNPLA3; Adiponutrin

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Goat

Human PNPLA3. This antibody is raised against a peptide derived from the Mouse protein sequence and this peptide differs from Human only in position 2.

Immunoaffinity Purified

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

0.5 mg/ml (lot specific)

Store at -20 degree C. Minimize freezing and thawing.

Small volumes of anti-PNPLA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

ELISA (1:128000), IHC-P (3.75 ug/ml), WB (0.05 - 0.2 ug/ml)

Anti-PNPLA3 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.

Antibody (0.05 ug/ml) staining of mouse heart lysate (35 ug protein in RIPA buffer). Primary incubation was 1hr. Detected by chemiluminescence.

52,485 Da

patatin-like phospholipase domain containing 3

patatin-like phospholipase domain-containing protein 3; adiponutrin; iPLA2epsilon; iPLA2-epsilon; acylglycerol O-acyltransferase; calcium-independent phospholipase A2-epsilon

Patatin-like phospholipase domain-containing protein 3

ADPN; C22orf20; iPLA2-epsilon??[Similar Products]

PLPL3_HUMAN

The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided by RefSeq, Jul 2008]

PNPLA3: Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities. Genetic variations in PNPLA3 are a cause of susceptibility to non-alcoholic fatty liver disease type 1 (NAFLD1). A condition characterized by an accumulation of excess triglyceride in the liver, a condition known as hepatic steatosis (or fatty liver), which is associated with adverse metabolic consequences, including insulin resistance and dyslipidemia. In a subset of individuals, hepatic steatosis promotes an inflammatory response in the liver, referred to as steatohepatitis, which can progress to cirrhosis and liver cancer. NAFLD is the most common form of liver disease in Western countries. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - glycerolipid; Transferase; Lipid Metabolism - glycerophospholipid; Secondary Metabolites Metabolism - limonene and pinene degradation; Phospholipase; Amino Acid Metabolism - tyrosine; Membrane protein, integral; EC 3.1.1.3; Amino Acid Metabolism - phenylalanine

Chromosomal Location of Human Ortholog: 22q13.31

Cellular Component: endoplasmic reticulum membrane; membrane; integral to membrane

Molecular Function: phospholipase A2 activity; triacylglycerol lipase activity; mono-olein transacylation activity; diolein transacylation activity

Biological Process: phospholipid metabolic process; glycerophospholipid biosynthetic process; triacylglycerol catabolic process; triacylglycerol biosynthetic process

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