NCC; TSC; NCCT

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

The antibody detects endogenous levels of total SLC12A3 protein.

Antigen affinity purification

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

0.8mg/ml (lot specific)

Store at -20 degree C

Small volumes of anti-SLC12A3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.

Total protein Ab

Immunohistochemistry (IHC)

Immunohistochemistry: 1: 20-100

The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using SLC12A3 Antibody at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200)

The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using SLC12A3 Antibody at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200)

113,808 Da

solute carrier family 12 member 3

solute carrier family 12 member 3

Solute carrier family 12 member 3

NCC; TSC; NCC??[Similar Products]

S12A3_HUMAN

This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

NCCT: Key mediator of sodium and chloride reabsorption in this nephron segment, accounting for a significant fraction of renal sodium reabsorption. Interacts with KLHL3. Predominant in kidney. Activated by WNK3. Belongs to the SLC12A transporter family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 16q13

Cellular Component: apical plasma membrane; integral to plasma membrane; membrane; plasma membrane

Molecular Function: protein binding; sodium:chloride symporter activity; transporter activity

Biological Process: ion transport; sodium ion transport; transport

Disease: Gitelman Syndrome

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