Product Name
B-lymphocyte antigen CD19 (Cd19), Recombinant Protein
Full Product Name
Recombinant Mouse B-lymphocyte antigen CD19 (Cd19)
Product Synonym Names
B-lymphocyte antigen CD19; Differentiation antigen CD19; CD_antigen=; CD19
Product Gene Name
Cd19 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
19-287, partial, provide the complete extracellular domain.
Sequence
RPQKSLLVEV EEGGNVVLPC LPDSSPVSSE KLAWYRGNQS TPFLELSPGS PGLGLHVGSL GILLVIVNVS DHMGGFYLCQ KRPPFKDIWQ PAWTVNVEDS GEMFRWNASD VRDLDCDLRN RSSGSHRSTS GSQLYVWAKD HPKVWGTKPV CAPRGSSLNQ SLINQDLTVA PGSTLWLSCG VPPVPVAKGS ISWTHVHPRR PNVSLLSLSL GGEHPVREMW VWGSLLLLPQ ATALDEGTYY CLRGNLTIER HVKVIARSAV WLWLLRTGG
3D Structure
ModBase 3D Structure for P25918
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Mus musculus (Mouse)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Cd19 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Cd19. It may not necessarily be applicable to this product.
NCBI Accession #
NP_033974.2
[Other Products]
NCBI GenBank Nucleotide #
NM_009844.2
[Other Products]
UniProt Primary Accession #
P25918
[Other Products]
UniProt Secondary Accession #
Q542B2[Other Products]
UniProt Related Accession #
P25918[Other Products]
Molecular Weight
60,149 Da
NCBI Official Full Name
B-lymphocyte antigen CD19
NCBI Official Synonym Full Names
CD19 antigen
NCBI Official Symbol
Cd19??[Similar Products]
NCBI Official Synonym Symbols
AW495831
??[Similar Products]
NCBI Protein Information
B-lymphocyte antigen CD19; differentiation antigen CD19
UniProt Protein Name
B-lymphocyte antigen CD19
UniProt Synonym Protein Names
Differentiation antigen CD19; CD_antigen: CD19
Protein Family
B-lymphocyte antigen
UniProt Gene Name
Cd19??[Similar Products]
UniProt Entry Name
CD19_MOUSE
UniProt Comments for Cd19
CD19: a cell surface molecule which assembles with the antigen receptor of B lymphocytes. A critical signal transduction molecule that regulates B lymphocyte development, activation, and differentiation. Ligation increases intracellular calcium levels and decreases the threshold for antigen receptor signaling. Germinal center formation is significantly reduced in CD19-deficient mice.
Protein type: Membrane protein, integral; Cell surface
Cellular Component: protein complex; membrane; integral to membrane; external side of plasma membrane
Biological Process: B cell receptor signaling pathway; positive regulation of release of sequestered calcium ion into cytosol
Research Articles on Cd19
1. This inhibitory function of FcgammaRIIB in impairing the spatial-temporal colocalization of BCR and CD19 microclusters in the B cell immunological synapse may help explain the hyper-reactive features of systemic lupus erythematosus
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
