Full Product Name
ABCG5 Polyclonal Antibody
Product Synonym Names
ATP-binding cassette sub-family G member 5; Sterolin-1; ABCG5
Product Gene Name
anti-ABCG5 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9H222
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Immunogen
Synthesized peptide derived from human protein. at AA range: 250-330
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-ABCG5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ABCG5 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-ABCG5 antibody
WB: 1:500-2000
ELISA: 1:5000-20000
NCBI/Uniprot data below describe general gene information for ABCG5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_071881.1
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NCBI GenBank Nucleotide #
NM_022436.2
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UniProt Primary Accession #
Q9H222
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UniProt Secondary Accession #
Q2T9G2; Q96QZ2; Q96QZ3[Other Products]
UniProt Related Accession #
Q9H222[Other Products]
NCBI Official Full Name
ATP-binding cassette sub-family G member 5
NCBI Official Synonym Full Names
ATP binding cassette subfamily G member 5
NCBI Official Symbol
ABCG5??[Similar Products]
NCBI Official Synonym Symbols
STSL
??[Similar Products]
NCBI Protein Information
ATP-binding cassette sub-family G member 5
UniProt Protein Name
ATP-binding cassette sub-family G member 5
UniProt Synonym Protein Names
Sterolin-1
Protein Family
ABC transporter G family
UniProt Gene Name
ABCG5??[Similar Products]
NCBI Summary for ABCG5
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCG5
ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg2+- and ATP-dependent sterol transport across the cell membrane (PubMed:27144356). Plays an essential role in the selective transport of dietary plant sterols and cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:11099417, PubMed:11138003, PubMed:27144356, PubMed:15054092). Required for normal sterol homeostasis (PubMed:11099417, PubMed:11138003, PubMed:15054092). The heterodimer with ABCG8 has ATPase activity (PubMed:16893193, PubMed:20210363, PubMed:27144356).
Research Articles on ABCG5
1. Case Reports: compound heterozygous for nonsense mutations in ABCG5 responsible for sitosterolemia.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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