Product Name
Nephrocystin-4 (NPHP4), Polyclonal Antibody
Full Product Name
Nephrocystin-4 Polyclonal Antibody
Product Gene Name
anti-NPHP4 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O75161
Other Notes
Small volumes of anti-NPHP4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for NPHP4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001278522.1
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NCBI GenBank Nucleotide #
NM_001291593.1
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UniProt Primary Accession #
O75161
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UniProt Secondary Accession #
Q8IWC0[Other Products]
UniProt Related Accession #
O75161[Other Products]
Molecular Weight
99,953 Da[Similar Products]
NCBI Official Full Name
nephrocystin-4 isoform b
NCBI Official Synonym Full Names
nephrocystin 4
NCBI Official Symbol
NPHP4??[Similar Products]
NCBI Official Synonym Symbols
POC10; SLSN4
??[Similar Products]
NCBI Protein Information
nephrocystin-4
UniProt Protein Name
Nephrocystin-4
UniProt Synonym Protein Names
Nephroretinin
Protein Family
Nephrocystin
UniProt Gene Name
NPHP4??[Similar Products]
UniProt Synonym Gene Names
KIAA0673??[Similar Products]
NCBI Summary for NPHP4
This gene encodes a protein involved in renal tubular development and function. This protein interacts with nephrocystin, and belongs to a multifunctional complex that is localized to actin- and microtubule-based structures. Mutations in this gene are associated with nephronophthisis type 4, a renal disease, and with Senior-Loken syndrome type 4, a combination of nephronophthisis and retinitis pigmentosa. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
UniProt Comments for NPHP4
Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module (PubMed:19755384, PubMed:21565611). Does not seem to be strictly required for ciliogenesis (PubMed:21565611). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (). In cooperation with INVS may downregulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (PubMed:21498478, PubMed:22654112). Acts as negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (PubMed:21555462).
Research Articles on NPHP4
1. Inherited 3 deleterious mutations in two nephronophthisis genes, NPHP3 and NPHP4 cause unusually severe form of infantile nephronophthisis.
Precautions
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