Product Name
Beta Defensin-14 (BD14), Recombinant Protein
Full Product Name
Recombinant Mouse Beta Defensin-14
Product Synonym Names
BD14 Mouse; Beta-defensin 14; BD-14; mBD-14; Defensin; beta 14; Defb14; Beta Defensin-14 Mouse Recombinant
Product Gene Name
BD14 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
FLPKTLRKFF CRIRGGRCAV LNCLGKEEQI GRCSNSGRKC CRKKK
3D Structure
ModBase 3D Structure for Q7TNV9
Purity/Purification
Greater than 96.0% as determined by: (a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Form/Format
Sterile filtered white lyophilized (freeze-dried) powder.
BD-14 protein was lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4.
Solubility
It is recommended to reconstitute the lyophilized BD14 in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Other Notes
Small volumes of BD14 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
BD14 recombinant protein
Description: Beta Defensin-14 Mouse Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 45 amino acids and having a molecular mass of 5.2kDa. The BD14 is purified by proprietary chromatographic techniques.
Introduction: Alpha and Beta Defensins are cationic peptides with antimicrobial activity against Gram-negative and Gram-positive bacteria, fungi and enveloped viruses. These 2-6kDa proteins have vital roles in innate immune system. Mammalian Defensins are classified into alpha, beta and theta categories, based on their size and pattern of disulfide bonding. Beta-Defensins contain a six-cysteine motif which forms 3 intra-molecular disulfide bonds. Since beta-defensins are cationic peptides, they can therefore interact with the membrane of invading microbes, which are negative due to lipopolysaccharides (LPS) and lipoteichoic acid (LTA) found in the cell membrane. In addition, they can affect the stability of the membrane.
Product Categories/Family for BD14 recombinant protein
CYTOKINES AND GROWTH FACTORS
NCBI/Uniprot data below describe general gene information for BD14. It may not necessarily be applicable to this product.
NCBI Accession #
NP_898847.1
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NCBI GenBank Nucleotide #
NM_183026.2
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UniProt Primary Accession #
Q7TNV9
[Other Products]
UniProt Secondary Accession #
Q14BD1[Other Products]
UniProt Related Accession #
Q7TNV9[Other Products]
Molecular Weight
7,718 Da
NCBI Official Full Name
beta-defensin 14
NCBI Official Synonym Full Names
defensin beta 14
NCBI Official Symbol
Defb14??[Similar Products]
NCBI Official Synonym Symbols
BD-14
??[Similar Products]
NCBI Protein Information
beta-defensin 14
UniProt Protein Name
Beta-defensin 14
UniProt Synonym Protein Names
Defensin, beta 14
UniProt Gene Name
Defb14??[Similar Products]
UniProt Synonym Gene Names
BD-14; mBD-14??[Similar Products]
UniProt Comments for BD14
Has antibacterial activity.
Research Articles on BD14
1. This study indicated that the potential antibacterial role of increased MBD-14 in the osteomyelitis mouse model.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
