Product Name
TPMT, cDNA Clone
Full Product Name
TPMT cDNA Clone
Product Gene Name
TPMT cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggatggta caagaacttc acttgacatt gaagagtact cggatactga ggtacagaaa aaccaagtac taactctgga agaatggcaa gacaagtggg tgaacggcaa gactgctttt catcaggaac aaggacatca gctattaaag aagcatttag atactttcct taaaggcaag agtggactga gggtattttt tcctctttgc ggaaaagcgg ttgagatgaa atggtttgca gaccggggac acagtgtagt tggtgtggaa atcagtgaac ttgggataca agaatttttt acagagcaga atctttctta ctcagaagaa ccaatcaccg aaattcctgg aaccaaagta tttaagagtt cttcggggaa catttcattg tactgttgca gtatttttga tcttcccagg acaaatattg gcaaatttga catgatttgg gatagaggag cattagttgc cattaatcca ggtgatcgca aatgctatgc agatacaatg ttttccctcc tgggaaagaa gtttcagtat ctcctgtgtg ttctttctta tgatccaact aaacatccag gtccaccatt ttatgttcca catgctgaaa ttgaaaggtt gtttggtaaa atatgcaata tacgttgtct tgagaaggtt gatgcttttg aagaacgaca taaaagttgg ggaattgact gtctttttga aaagttatat ctacttacag aaaagtaa
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of TPMT cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for TPMT. It may not necessarily be applicable to this product.
NCBI Accession #
BC009596
[Other Products]
UniProt Secondary Accession #
O14806; O15423; O15424; O15425; O15426; O15515; O15548; O43213; Q5VUK6; Q9UBE6; Q9UBT8[Other Products]
UniProt Related Accession #
P51580[Other Products]
Molecular Weight
28,180 Da
NCBI Official Full Name
Homo sapiens thiopurine S-methyltransferase, mRNA
NCBI Official Synonym Full Names
thiopurine S-methyltransferase
NCBI Official Symbol
TPMT??[Similar Products]
NCBI Official Synonym Symbols
TPMTD
??[Similar Products]
NCBI Protein Information
thiopurine S-methyltransferase
UniProt Protein Name
Thiopurine S-methyltransferase
UniProt Synonym Protein Names
Thiopurine methyltransferase
UniProt Gene Name
TPMT??[Similar Products]
UniProt Entry Name
TPMT_HUMAN
NCBI Summary for TPMT
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]
UniProt Comments for TPMT
TPMT: Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. Defects in TPMT are the cause of thiopurine S- methyltransferase deficiency (TPMT deficiency). TPMT is an enzyme involved in the normal metabolic inactivation of thiopurine drugs. These drugs are generally used as immunosupressants or cytotoxic drugs and are prescribed for a variety of clinical conditions including leukemia, autoimmune disease and organ transplantation. Patients with intermediate or no TPMT activity are at risk of toxicity after receiving standard doses of thiopurine drugs and it is shown that inter-individual differences in response to these drugs are largely determined by genetic variation at the TPMT locus. Belongs to the methyltransferase superfamily. TPMT family.
Protein type: Xenobiotic Metabolism - drug metabolism - other enzymes; EC 2.1.1.67; Methyltransferase
Chromosomal Location of Human Ortholog: 6p22.3
Cellular Component: cytosol
Molecular Function: thiopurine S-methyltransferase activity
Biological Process: methylation; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Disease: Thiopurine S-methyltransferase Deficiency
Research Articles on TPMT
1. The TPMT promoter region may serve as a pharmacogenomic biomarker when introducing thiopurine therapy
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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