Anti-Muellerian hormone type-2 receptor; Anti-Muellerian hormone type II receptor; AMH type II receptor; MIS type II receptor; MISRII; MRII; AMHR2; AMHR; MISR2

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This AMHR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 374-402 amino acids from the C-terminal region of human AMHR2.

Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-AMHR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The AMH receptor (AMHR or AMHR2) is a serine/threonine kinase with a single transmembrane domain belonging to the family of type II receptors for TGF-beta-related proteins. Anti-Mullerian hormone (AMH) and its receptor are involved in the regression of Mullerian ducts in male fetuses. Male sex differentiation is mediated by 2 discrete hormones produced by the fetal testis. Testosterone, produced by Leydig cells, virilizes the external genitalia and promotes prostatic growth; anti-Mullerian hormone (AMH) results in regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes.

Signal Transduction

Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS)

WB~~1:1000
FC~~1:10~50

Western blot analysis of AMHR2 Antibody (C-term) in CEM cell line lysates (35ug/lane).AMHR2 (arrow) was detected using the purified Pab.

Flow cytometric analysis of CEM cells using AMHR2 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Western blot analysis of AMHR2 Antibody (C-term) in CEM cell line lysates (35ug/lane).AMHR2 (arrow) was detected using the purified Pab.

Flow cytometric analysis of CEM cells using AMHR2 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

anti-Mullerian hormone receptor, type II

anti-Muellerian hormone type-2 receptor

Anti-Muellerian hormone type-2 receptor

AMHR; MISR2; AMH type II receptor; MISRII; MRII??[Similar Products]

AMHR2_HUMAN

This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2009]

MISR2: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Protein type: Kinase, protein; Protein kinase, TKL; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); EC 2.7.11.30; TKL group; STKR family; Type2 subfamily

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: integral to plasma membrane

Molecular Function: protein binding; hormone binding; transforming growth factor beta receptor activity, type II; metal ion binding; receptor activity; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: Mullerian duct regression; transforming growth factor beta receptor signaling pathway; signal transduction; protein amino acid phosphorylation; sex differentiation

Disease: Persistent Mullerian Duct Syndrome, Types I And Ii

Picard, J.Y., et al., J. Soc. Biol. 196(3):217-221 (2002).
Teixeira, J., et al., Endocr. Rev. 22(5):657-674 (2001).
Imbeaud, S., et al., Nat. Genet. 11(4):382-388 (1995).
Visser, J.A., et al., Biochem. Biophys. Res. Commun. 215(3):1029-1036 (1995).
Sinisi, A.A., et al., J. Endocrinol. Invest. 26 (3 Suppl), 23-28 (2003).

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.