Anti -HLA Class 1 Antigen B8 (FITC)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 6; NC_000006.11 (31321649..31324989, complement). Location: 6p21.3

Monoclonal

IgG2b

0.L.3

Mouse

Recognizes human HLA Class 1 Antigen B8.

Highly Purified
Purified by Ion Exchange chromatography (98%).

Supplied as a liquid in PBS, 0.05% sodium azide, 0.5% BSA. Labeled with FITC. FITC/Protein Ratio: 4-8.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. FITC conjugates are sensitive to light.

Small volumes of anti-HLA-B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Antibodies can also be used for the detection of HLA antigens on the lymphocytes in whole blood samples and cells isolated from blood or lymphoid tissue. The HLA Class 1 conjugated monoclonal antibodies can be used for the detection of specific cell surface antigens.

Antibodies; Abs to HLA

Flow Cytometry (FC/FACS), Immunofluorescence (IF)

Suitable for use in Flow Cytometry, Cell Typing, Tissue Staining and Chimerism Studies.

20,980 Da[Similar Products]

major histocompatibility complex, class I, B

major histocompatibility complex, class I, B; OTTHUMP00000029212; lymphocyte antigen; MHC class I antigen SHCHA; MHC Class I HLA heavy chain; MHC class I antigen GN00104; leukocyte antigen class I-B; MHC HLA-B cell surface glycoprotein; MHC HLA-B transmembrane glycoprotein; MHC class I antigen HLA-B heavy chain; HLA class I histocompatibility antigen, B alpha chain

MHC class I antigen

O02861_HUMAN

HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq]

Sequence similarities: Belongs to the MHC class I family. RuleBase RU004439

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