AMHR; MRII; MISR2; MISRII

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

The antibody detects endogenous levels of total AMHR2 protein.

Antigen affinity purification.

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

1.4 mg/ml (lot specific)

Store at -20 degree C

Small volumes of anti-AMHR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified.

Total protein Ab

Immunohistochemistry (IHC)

Immunohistochemistry: 1:50-1:200

Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue using at dilution 1/40.

Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using at dilution 1/40.

51,827 Da

anti-Mullerian hormone receptor, type II

anti-Muellerian hormone type-2 receptor

Anti-Muellerian hormone type-2 receptor

AMHR; MISR2; AMH type II receptor; MISRII; MRII??[Similar Products]

AMHR2_HUMAN

This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2009]

MISR2: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Protein type: Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Kinase, protein; Protein kinase, TKL; EC 2.7.11.30; TKL group; STKR family; Type2 subfamily

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: integral to plasma membrane

Molecular Function: protein binding; hormone binding; transforming growth factor beta receptor activity, type II; metal ion binding; receptor activity; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: Mullerian duct regression; transforming growth factor beta receptor signaling pathway; signal transduction; protein amino acid phosphorylation; sex differentiation

Disease: Persistent Mullerian Duct Syndrome, Types I And Ii

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