Anti -BMP15, NT (Bone Morphogenetic Protein 15, BMP-15, Growth/Differentiation Factor 9B, GDF-9B, GDF9B)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: X; NC_000023.10 (50653735..50659641). Location: Xp11.2

Polyclonal

Rabbit

Recognizes human BMP15.

Affinity Purified
Purified by immunoaffinity chromatography.

Supplied as a liquid in PBS, 0.02% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-BMP15 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Bmp15 is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The transforming growth factor-beta superfamily includes large families of growth and differentiation factors. It is thought that Bmp15 may be involved in oocyte maturation and follicular development as a homodimer or by forming heterodimers with a related protein, Gdf9.

Antibodies; Abs to Growth Factors, Cytokines

Immunohistochemistry (IHC)

Suitable for use in Immunohistochemistry.
Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml

45,055 Da[Similar Products]

bone morphogenetic protein 15

bone morphogenetic protein 15; BMP-15; GDF-9B; growth/differentiation factor 9B

Bone morphogenetic protein 15

GDF9B; BMP-15; GDF-9B??[Similar Products]

BMP15_HUMAN

The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The transforming growth factor-beta superfamily includes large families of growth and differentiation factors. It is thought that this protein may be involved in oocyte maturation and follicular development as a homodimer or by forming heterodimers with a related protein, Gdf9. Defects in this gene are the cause of ovarian dysgenesis 2.[provided by RefSeq, Sep 2009]

BMP15: May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. Defects in BMP15 are the cause of ovarian dysgenesis type 2 (ODG2); also known as X-linked hypergonadotropic ovarian dysgenesis or hypergonadotropic ovarian failure due to ovarian dysgenesis. Ovarian dysgenesis leads to ovarian failure and accounts for about half of the cases of primary amenorrhea. Defects in BMP15 are the cause of premature ovarian failure type 4 (POF4). An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide; Cytokine

Chromosomal Location of Human Ortholog: Xp11.2

Cellular Component: extracellular space; cytoplasm

Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: BMP signaling pathway; regulation of apoptosis; granulosa cell development; ovarian follicle development; positive regulation of transcription, DNA-dependent; regulation of MAPKKK cascade; female gamete generation; cell development

Disease: Ovarian Dysgenesis 2

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