Full Product Name
Anti-ALAD Antibody
Product Synonym Names
Delta-aminolevulinic acid dehydratase; ALADH; Porphobilinogen synthase
Product Gene Name
anti-ALAD antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P13716
Specificity
Recognizes endogenous levels of ALAD protein.
Purity/Purification
Purified by immunogen affinity chromatography
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
Recombinant full length protein of human ALAD
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-ALAD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ALAD antibody
Rabbit polyclonal antibody to ALAD
Applications Tested/Suitable for anti-ALAD antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ALAD antibody
WB: 1/500 - 1/2000
IHC: 1/50 - 1/200
Western Blot (WB) of anti-ALAD antibody
Western blot analysis of ALAD expression in MCF7 (A), HL60 (B) whole cell lysates.
NCBI/Uniprot data below describe general gene information for ALAD. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000022.3
[Other Products]
NCBI GenBank Nucleotide #
NM_000031.5
[Other Products]
UniProt Primary Accession #
P13716
[Other Products]
UniProt Secondary Accession #
Q16870; Q16871; Q9BVQ9; A8K375; B2R6F2[Other Products]
UniProt Related Accession #
P13716[Other Products]
Molecular Weight
39,034 Da
NCBI Official Full Name
delta-aminolevulinic acid dehydratase isoform b
NCBI Official Synonym Full Names
aminolevulinate dehydratase
NCBI Official Symbol
ALAD??[Similar Products]
NCBI Official Synonym Symbols
PBGS; ALADH
??[Similar Products]
NCBI Protein Information
delta-aminolevulinic acid dehydratase
UniProt Protein Name
Delta-aminolevulinic acid dehydratase
UniProt Synonym Protein Names
Porphobilinogen synthase
UniProt Gene Name
ALAD??[Similar Products]
UniProt Synonym Gene Names
ALADH??[Similar Products]
NCBI Summary for ALAD
The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
UniProt Comments for ALAD
Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
Research Articles on ALAD
1. Overexpression of delta-aminolevulinate dehydratase (ALAD)suppresses breast cancer cell proliferation and invasion and inhibits the epithelial-mesenchymal transition phenotype.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
