Product Name
Mu-type opioid receptor (OPRM1), Protein
Full Product Name
Mu-type opioid receptor
Product Synonym Names
Ror-b; Opioid receptor B
Product Gene Name
OPRM1 protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-66aa
3D Structure
ModBase 3D Structure for P33535
Purity/Purification
>95% by SDS-PAGE
Endotoxin Level
<0.10 EU per 1 mug of the protein by the LAL method
Storage Buffer
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
Preparation and Storage
Store at -20 degree C.
Avoid repeated freezing and thawing.
Other Notes
Small volumes of OPRM1 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for OPRM1 protein
Neurosciences
Applications Tested/Suitable for OPRM1 protein
ELISA (EIA), Western Blot (WB), Affinity Purification (AP), Protein Array
NCBI/Uniprot data below describe general gene information for OPRM1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001033686.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001038597.2
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UniProt Primary Accession #
P33535
[Other Products]
UniProt Secondary Accession #
Q2TV20; Q2TV21; Q4VWM5; Q4VWM7; Q4VWX7; Q4VWX8; Q62846; Q64064; Q64120[Other Products]
UniProt Related Accession #
P33535[Other Products]
Molecular Weight
43,317 Da
NCBI Official Full Name
mu-type opioid receptor isoform IA
NCBI Official Synonym Full Names
opioid receptor, mu 1
NCBI Official Symbol
Oprm1??[Similar Products]
NCBI Official Synonym Symbols
MORA; Oprm; Oprrm1
??[Similar Products]
NCBI Protein Information
mu-type opioid receptor
UniProt Protein Name
Mu-type opioid receptor
UniProt Synonym Protein Names
Opioid receptor B
Protein Family
Mu-type opioid receptor
UniProt Gene Name
Oprm1??[Similar Products]
UniProt Synonym Gene Names
Ror-b; M-OR-1; MOR-1??[Similar Products]
NCBI Summary for OPRM1
receptor that binds morphine with high affinity [RGD, Feb 2006]
UniProt Comments for OPRM1
Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extend to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation. Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling. Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling. Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. Involved in neurogenesis.
Research Articles on OPRM1
1. results provide further evidence for the role of accumbens shell mu-opioid receptors but not kappa-opioid receptors in mediating reinforcing e ff ects of EtOH and in regulating EtOH consumption.
Precautions
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