Mu-type opioid receptor; M-OR-1; MOR-1; Opioid receptor B; Oprm1; Ror-b

For Research Use Only. Not for use in diagnostic procedures.

Store at 4 degree C

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Small volumes of Oprm1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9426013 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Mu-type opioid receptor (Oprm1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Oprm1. The ELISA analytical biochemical technique of the MBS9426013 kit is based on Oprm1 antibody-Oprm1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Oprm1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Oprm1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

43,317 Da

opioid receptor, mu 1

mu-type opioid receptor

Mu-type opioid receptor

Ror-b; M-OR-1; MOR-1??[Similar Products]

receptor that binds morphine with high affinity [RGD, Feb 2006]

MOR-1: a Gi-protein-coupled receptor for beta-endorphin, morphine and other opiates. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Ligand-binding inactivates adenylyl cyclase, and activates a variety of G-beta-gamma-dependent pathways including the MAPK and the PI3K/Akt cascades. Two splice-variant isoforms have been described.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 1q11

Cellular Component: axon; cytoplasm; dendrite; dendrite cytoplasm; endosome; focal adhesion; integral to plasma membrane; lipid raft; membrane; perikaryon; sarcolemma

Molecular Function: beta-endorphin receptor activity; filamin binding; G-protein alpha-subunit binding; G-protein beta-subunit binding; G-protein coupled receptor activity; neuropeptide binding; opioid receptor activity; protein binding; protein C-terminus binding; protein domain specific binding; voltage-gated calcium channel activity

Biological Process: acute inflammatory response to antigenic stimulus; behavioral response to ethanol; dopamine receptor, adenylate cyclase activating pathway; eating behavior; elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); immune response; locomotory behavior; negative regulation of adenylate cyclase activity; negative regulation of cAMP biosynthetic process; negative regulation of nitric oxide biosynthetic process; opioid receptor, adenylate cyclase inhibiting pathway; positive regulation of appetite; positive regulation of neurogenesis; positive regulation of nitric oxide biosynthetic process; reduction of cytosolic calcium ion concentration; regulation of excitatory postsynaptic membrane potential; regulation of sensory perception of pain; response to cocaine; response to ethanol; response to food; response to lipopolysaccharide; response to morphine; response to radiation; sensory perception of pain; wound healing

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