Product Name
TMEM67, cDNA Clone
Full Product Name
TMEM67 cDNA Clone
Product Gene Name
TMEM67 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggcggttt ggtccctctt atccgcccgg gccgtgaccg cgttccttct gttgttcctc cctcgcttct tacaggccca gaccttctct ttccctttcc agcagccgga gaagtgcgac aacaaccagt actttgatat ctccgccctc tcgtgtgttc cttgtggagc taaccagagg caagatgccc gaggaacttc atgtgtatgt ctaccaggat ttcagatgat ctctaataat ggaggacctg ctattatttg taaaaagtgc ccagaaaaca tgaaaggtgt tacagaagat ggctggaact gcatttcttg ccctagtgac ttaactgccg aaggaaaatg tcactgtccc attggccata ttttagtgga aagagacatt aatggaacat tgttgtctca agcaacttgt gagctctgtg atggaaatga aaactctttt atggtagtaa atgctttagg agacaggtgc gtccgatgtg agccaacatt tgttaatacc agcaggtcct gtgcatgttc agaacctaac attttaacag ggggattatg tttcagcagc acagggaatt ttcctctacg tagaatttca gctgcacgtt atggagaagt tggcatgtct ttaacttcag aatggtttgc aaagtatttg caatcatcag cagctgcatg ttgggtatat gccaatctaa catcttgtca agctcttgga aatatgtgtg tgatgaacat gaattcttac gactttgcca catttgatgc atgtggacta tttcagttta tctttgaaaa tactgctgga ctgagcactg ttcattctat ttcattttgg agacagaatc ttccttggct gttttatgga gaccagttag gattagcacc tcaagtgctc agttctacct ctcttcctac aaatttcagt tttaaaggag aaaaccagaa tacaaaactg aagtttgttg ctgcttccta tgatataaga ggaaattttc tcaagtggca aactttagaa ggaggtgttt tacagctttg tccagacaca gagacaaggc taaatgctgc ttattcattt ggaacaacct accaacaaaa ttgtgagatt cctatctcta agatcttaat tgactttccc actcctatat tttatgatgt gtaccttgaa tatactgatg aaaatcaaca tcaatatatt ttggctgtgc ctgtgttaaa cctaaatctt caacataata agatatttgt gaaccaagac agcaactctg gaaagtggct tctaactcgg cgcattttct tagtggatgc agtaagtgga cgagaaaatg acttaggaac tcagccaaga gtaattcgag ttgctactca aatatcactg agtgtccacc ttgtacccaa cacaataaat ggaaacatct accctccctt aatcaccatt gcctacagtg acattgatat caaagatgcc aacagccagt ctgtgaaggt ttctttctca gtcacatatg aaatggatca tggagaagca catgtccaga cagatattgc tttgggtgta ttgggtgggc tagctgtttt agcatctctt ttgaagacag caggatggaa gaggcgcatt gggagtccca tgattgattt acagacagtt gtgaaattct tggtgtacta tgctggtgat ctggccaatg ttttctttat catcacagtg ggaacaggtc tttactggct tattttcttc aaagcacaga agtctgtgtc tgttttgctg ccaatgccaa ttcaggaaga acgttttgtc acttatgttg gatgtgcctt tgctctgaag gcactacaat ttttgcataa gctcatatcc cagattacaa tagatgtatt ctttattgat tgggagcgac ctaaaggaaa ggttcttaaa gctgttgaag gtgagggtgg tgtacgaagt gccactgttc ctgtaagcat atggagaaca tattttgtag caaatgaatg gaatgaaatt cagactgtga gaaaaattaa ttcactcttt caagtactta ctgtcctctt ctttttggag gttgtgggat tcaagaactt agcattaatg gactcatctt ctagtctttc tagaaaccca cctagctaca tagctcctta tagctgcatt ttgagatatg cagtgtctgc tgctctttgg ctagccattg gaattataca ggtcgtgttc tttgctgtct tttatgagag atttatagaa gataaaattc gacagttcgt tgatttatgc tctatgagta atatatcagt gtttctgtta tcccacaaat gttttggata ttacattcat ggtagatcag tacatgggca tgcagatact aatatggaag aaatgaatat gaaccttaaa agagaagcgg aaaatttgtg tagccagaga ggtttggtac ccaacacaga tggtcagact tttgagattg caatttctaa ccagatgaga caacattatg acagaattca tgagacacta ataaggaaaa atggtcctgc tagactactg agttcatcag caagtacttt tgagcagagt ataaaagcat atcatatgat gaataaattt cttggctcct tcattgacca tgttcataag gaaatggatt actttataaa agataagttg cttcttgaaa gaattcttgg aatggaattc atggaaccaa tggaaaaaag catcttttac aatgatgaag gttattcttt cagcagtgtc ctgtattatg gaaatgaagc tactcttctt atttttgatc tgctgttctt ctgtgttgtg gatttggctt gccaaaattt tattttagca tccttcctta catatctaca acaagagatt tttagatata tccgtaatac agtaggacaa aagaatttgg catccaaaac attggtggat caaagatttt tgatttaa
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of TMEM67 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for TMEM67. It may not necessarily be applicable to this product.
NCBI Accession #
BC032835
[Other Products]
UniProt Secondary Accession #
Q3ZCX3; Q7Z5T8; Q8IZ06; B3KRU5; B3KT47; G5E9H2[Other Products]
UniProt Related Accession #
Q5HYA8[Other Products]
Molecular Weight
103,590 Da
NCBI Official Full Name
Homo sapiens transmembrane protein 67, mRNA
NCBI Official Synonym Full Names
transmembrane protein 67
NCBI Official Symbol
TMEM67??[Similar Products]
NCBI Official Synonym Symbols
MKS3; JBTS6; NPHP11; TNEM67; MECKELIN
??[Similar Products]
NCBI Protein Information
meckelin
UniProt Protein Name
Meckelin
UniProt Synonym Protein Names
Meckel syndrome type 3 protein; Transmembrane protein 67
UniProt Gene Name
TMEM67??[Similar Products]
UniProt Synonym Gene Names
MKS3??[Similar Products]
UniProt Entry Name
MKS3_HUMAN
NCBI Summary for TMEM67
The protein encoded by this gene localizes to the primary cilium and to the plasma membrane. The gene functions in centriole migration to the apical membrane and formation of the primary cilium. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Meckel syndrome type 3 (MKS3) and Joubert syndrome type 6 (JBTS6). [provided by RefSeq, Nov 2008]
UniProt Comments for TMEM67
TMEM67: a protein localizes to the primary cilium and to the plasma membrane. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC). Ciliary dysfunction leads to a broad spectrum of disorders, collectively termed ciliopathies. Defects in this protein are a cause of Meckel syndrome type 3 (MKS3) and Joubert syndrome type 6 (JBTS6). Overlapping clinical features include retinal degeneration, renal cystic disease, skeletal abnormalities, fibrosis of various organ, and a complex range of anatomical and functional defects of the central and peripheral nervous system. Interacts with DNAJB9, DNAJC10, MKS1 and mutated SFTPC. Interacts with SYNE2 during the early establishment of cell polarity.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 8q22.1
Cellular Component: centrosome; cytoplasmic vesicle membrane; endoplasmic reticulum membrane
Molecular Function: filamin binding; protein binding; unfolded protein binding
Biological Process: cilium biogenesis; ER-associated protein catabolic process
Disease: Bardet-biedl Syndrome 1; Bardet-biedl Syndrome 14; Coach Syndrome; Joubert Syndrome 6; Meckel Syndrome, Type 3; Nephronophthisis 11
Research Articles on TMEM67
1. The Meckel syndrome protein meckelin (TMEM67) is a key regulator of cilia function but is not required for tissue planar polarity.
Precautions
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Disclaimer
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