Anti -CYBRD1, CT (Cytochrome B Reductase 1, Duodenal Cytochrome B, Ferric-chelate Reductase 3, DCYTB, FRRS3)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 2; NC_000002.11 (172378757..172414643). Location: 2q31.1

Polyclonal

Goat

Recognizes human CYBRD1. Species sequence homology: bovine, canine and porcine.

Affinity Purified
Purified by immunoaffinity chromatography.

Supplied as a liquid in Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-CYBRD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Antibodies; Abs to Enzymes, Cytochrome

ELISA (EL/EIA), Immunohistochemistry (IHC)

Suitable for use in ELISA and Immunohistochemistry.
Dilution: ELISA: 1:16,000
Immunohistochemistry (Formalin fixed paraffin embedded): 2.5ug/ml

31,641 Da[Similar Products]

cytochrome b reductase 1

cytochrome b reductase 1; duodenal cytochrome b; ferric-chelate reductase 3; cytochrome b561 family, member A2

Cytochrome b reductase 1

DCYTB; FRRS3??[Similar Products]

CYBR1_HUMAN

This gene is a member of the cytochrome b(561) family that encodes an iron-regulated protein. It highly expressed in the duodenal brush border membrane. It has ferric reductase activity and is believed to play a physiological role in dietary iron absorption. [provided by RefSeq, Jul 2008]

CYBRD1: Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, iron; Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, ion channel; Oxidoreductase; EC 1.-.-.-; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: brush border membrane; integral to membrane; plasma membrane

Molecular Function: oxidoreductase activity, oxidizing metal ions; metal ion binding; ferric-chelate reductase activity

Biological Process: cellular iron ion homeostasis; response to iron ion; transmembrane transport

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