Complement factor B [Precursor]; EC 3.4.21.47; C3/C5 convertase; Properdin factor B; Glycine-rich beta glycoprotein; GBG; PBF2; Complement factor B Ba fragment; Complement factor B Bb fragment; CFB; BF; BFD

For Research Use Only. Not for use in diagnostic procedures.

CFAB Bb (Cleaved-Lys260) antibody detects endogenous levels of fragment of activated CFAB Bb resulting from cleavage adjacent to Lys260.

Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Store at-20 degree C for 1 year.

Small volumes of anti-CFAB Bb antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), ELISA (EIA)

WB: 1:500~1:1000
ELISA: 1:20000

Western blot analysis of extracts from K562 cells, treated with etoposide (25uM, 1hour), using CFAB Bb (Cleaved-Lys260) antibody.

68,872 Da

complement factor B

complement factor B

Complement factor B

BF; BFD; GBG??[Similar Products]

This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]

Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.

Davrinche C., Immunogenetics 32:309-312(1990). Mejia J.E., Hum. Immunol. 39:49-53(1994). Schwaeble W., Immunobiology 188:221-232(1993).

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