Product Name
CFB, cDNA Clone
Popular Item
Full Product Name
CFB cDNA Clone
Product Gene Name
CFB cdna clone
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggggagca atctcagccc ccaactctgc ctgatgccct ttatcttggg cctcttgtct ggaggtgtga ccaccactcc atggtctttg gcctggcccc agggatcctg ctctctggag ggggtagaga tcaaaggcgg ctccttccga cttctccaag agggccaggc actggagtac gtgtgtcctt ctggcttcta cccgtaccct gtgcagacac gtacctgcag atctacgggg tcctggagca ccctgaagac tcaagaccaa aagactgtca ggaaggcaga gtgcagagca atccactgtc caagaccaca cgacttcgag aacggggaat actggccccg gtctccctac tacaatgtga gtgatgagat ctctttccac tgctatgacg gttacactct ccggggctct gccaatcgca cctgccaagt gaatggccgg tggagtgggc agacagcgat ctgtgacaac ggagcggggt actgctccaa cccgggcatc cccattggca caaggaaggt gggcagccag taccgccttg aagacagcgt cacctaccac tgcagccggg ggcttaccct gcgtggctcc cagcggcgaa cgtgtcagga aggtggctct tggagcggga cggagccttc ctgccaagac tccttcatgt acgacacccc tcaagaggtg gccgaagctt tcctgtcttc cctgacagag accatagaag gagtcgatgc tgaggatggg cacggcccag gggaacaaca gaagcggaag atcgtcctgg acccttcagg ctccatgaac atctacctgg tgctagatgg atcagacagc attggggcca gcaacttcac aggagccaaa aagtgtctag tcaacttaat tgagaaggtg gcaagttatg gtgtgaagcc aagatatggt ctagtgacat atgccacata ccccaaaatt tgggtcaaag tgtctgaagc agacagcagt aatgcagact gggtcacgaa gcagctcaat gaaatcaatt atgaagacca caagttgaag tcagggacta acaccaagaa ggccctccag gcagtgtaca gcatgatgag ctggccagat gacgtccctc ctgaaggctg gaaccgcacc cgccatgtca tcatcctcat gactgatgga ttgcacaaca tgggcgggga cccaattact gtcattgatg agatccggga cttgctatac attggcaagg atcgcaaaaa cccaagggag gattatctgg atgtctatgt gtttggggtc gggcctttgg tgaaccaagt gaacatcaat gctttggctt ccaagaaaga caatgagcaa catgtgttca aagtcaagga tatggaaaac ctggaagatg ttttctacca aatgatcgat gaaagccagt ctctgagtct ctgtggcatg gtttgggaac acaggaaggg taccgattac cacaagcaac catggcaggc caagatctca gtcattcgcc cttcaaaggg acacgagagc tgtatggggg ctgtggtgtc tgagtacttt gtgctgacag cagcacattg tttcactgtg gatgacaagg aacactcaat caaggtcagc gtaggagggg agaagcggga cctggagata gaagtagtcc tatttcaccc caactacaac attaatggga aaaaagaagc aggaattcct gaattttatg actatgacgt tgccctgatc aagctcaaga ataagctgaa atatggccag actatcaggc ccatttgtct cccctgcacc gagggaacaa ctcgagcttt gaggcttcct ccaactacca cttgccagca acaaaaggaa gagctgctcc ctgcacagga tatcaaagct ctgtttgtgt ctgaggagga gaaaaagctg actcggaagg aggtctacat caagaatggg gataagaaag gcagctgtga gagagatgct caatatgccc caggctatga caaagtcaag gacatctcag aggtggtcac ccctcggttc ctttgtactg gaggagtgag tccctatgct gaccccaata cttgcagagg tgattctggc ggccccttga tagttcacaa gagaagtcgt ttcattcaag ttggtgtaat cagctgggga gtagtggatg tctgcaaaaa ccagaagcgg caaaagcagg tacctgctca cgcccgagac tttcacatca acctctttca agtgctgccc tggctgaagg agaaactcca agatgaggat ttgggttttc tataa
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CFB cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CFB. It may not necessarily be applicable to this product.
NCBI Accession #
BC004143
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UniProt Secondary Accession #
O15006; Q29944; Q53F89; Q5JP67; Q5ST50; Q96HX6; Q9BTF5; Q9BX92; B0QZQ6[Other Products]
UniProt Related Accession #
P00751[Other Products]
Molecular Weight
68,872 Da
NCBI Official Full Name
Homo sapiens complement factor B, mRNA
NCBI Official Synonym Full Names
complement factor B
NCBI Official Symbol
CFB??[Similar Products]
NCBI Official Synonym Symbols
BF; FB; BFD; GBG; CFAB; CFBD; PBF2; AHUS4; FBI12; H2-Bf; ARMD14
??[Similar Products]
NCBI Protein Information
complement factor B
UniProt Protein Name
Complement factor B
UniProt Synonym Protein Names
C3/C5 convertase; Glycine-rich beta glycoprotein; GBG
Protein Family
Complement factor
UniProt Gene Name
CFB??[Similar Products]
UniProt Synonym Gene Names
BF; BFD; GBG??[Similar Products]
UniProt Entry Name
CFAB_HUMAN
NCBI Summary for CFB
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]
UniProt Comments for CFB
CFB: Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B- lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes. Defects in CFB are a cause of susceptibility to hemolytic uremic syndrome atypical type 4 (AHUS4). An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.21.47; Protease; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: extracellular region; extracellular space; plasma membrane
Molecular Function: complement binding; serine-type endopeptidase activity
Biological Process: complement activation; complement activation, alternative pathway; regulation of complement activation
Disease: Complement Factor B Deficiency; Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 4; Macular Degeneration, Age-related, 14
Research Articles on CFB
1. P serum level expression could be a reliable clinical biomarker to identify patients with underlying surface alternative pathway C5 convertase dysregulation.
Precautions
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Disclaimer
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