Mouse Monoclonal (IgG2b) to Human CFB/Complement Factor B; CFB; AHUS4; B-factor; properdin; C3/C5 convertase; CFAB; C3 proaccelerator; C3 proactivator; Complement factor B; Complement protein Factor B; Glycine-rich beta-glycoprotein; GBG; Factor B; FB; Glycine-rich beta glycoprotein; PBF2; BF; BFD; FBI12; H2-Bf; Properdin factor B

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Human CFB/Complement Factor B

Caprylic acid and ammonium sulfate precipitation

PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.

Aliquot and store at -20 degree C or -80 degree C. Avoid freeze-thaw cycles.

Small volumes of anti-CFB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Complement Factor B is complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternativepathway, it is cleaved by complement factor D yielding the noncatalyticchain Ba and the catalytic subunit Bb. the active subunit Bb is aserine protease which associates with C3b to form the alternativepathway C3 convertase.

Protease; Serine S1

ELISA (EIA), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

IHC-P: 7.5 ug/ml

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE). This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot of Complement factor B antibody at 2 ug/ml lane 1: K562 whole cell lysate lane 2: HepG2 whole cell lysate. Secondary: Goat polyclonal to rabbit at 1:10000 dilution predicted band size: 86 KDa observed band size: 86 KDa. This image was taken for the unconjugated form of this product. Other forms have not been tested.

68,872 Da

complement factor B

complement factor B

Complement factor B

BF; BFD; GBG??[Similar Products]

This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]

Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.

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