Product Name
TMEM67, Polyclonal Antibody
Full Product Name
TMEM67 Antibody
Product Synonym Names
MKS3; JBTS6; NPHP11; TNEM67; MECKELIN
Product Gene Name
anti-TMEM67 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q5HYA8
Specificity
The antibody detects endogenous levels of total TMEM67 protein.
Purity/Purification
Antigen affinity purification
Form/Format
In pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Concentration
0.1mg/ml (lot specific)
Immunogen
Fusion protein of human TMEM67
Preparation and Storage
Store at -20 degree C.
Other Notes
Small volumes of anti-TMEM67 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TMEM67 antibody
The protein encoded by this gene localizes to the primary cilium and to the plasma membrane. The gene functions in centriole migration to the apical membrane and formation of the primary cilium. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Meckel syndrome type 3 (MKS3) and Joubert syndrome type 6 (JBTS6).
Product Categories/Family for anti-TMEM67 antibody
Total protein Ab
Applications Tested/Suitable for anti-TMEM67 antibody
Immunohistochemistry (IHC)
Application Notes for anti-TMEM67 antibody
IF: 1: 20-100
Immunohistochemistry (IHC) of anti-TMEM67 antibody
The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 47101(ELANE Antibody) at dilution 1/25. (Original magnification: 200)
NCBI/Uniprot data below describe general gene information for TMEM67. It may not necessarily be applicable to this product.
NCBI Accession #
BC032835
[Other Products]
UniProt Primary Accession #
Q5HYA8
[Other Products]
UniProt Secondary Accession #
Q3ZCX3; Q7Z5T8; Q8IZ06; B3KRU5; B3KT47; G5E9H2[Other Products]
UniProt Related Accession #
Q5HYA8[Other Products]
NCBI Official Full Name
Homo sapiens transmembrane protein 67, mRNA
NCBI Official Synonym Full Names
transmembrane protein 67
NCBI Official Symbol
TMEM67??[Similar Products]
NCBI Official Synonym Symbols
MKS3; JBTS6; NPHP11; TNEM67; MECKELIN
??[Similar Products]
NCBI Protein Information
meckelin
UniProt Protein Name
Meckelin
UniProt Synonym Protein Names
Meckel syndrome type 3 protein; Transmembrane protein 67
UniProt Gene Name
TMEM67??[Similar Products]
UniProt Synonym Gene Names
MKS3??[Similar Products]
NCBI Summary for TMEM67
The protein encoded by this gene localizes to the primary cilium and to the plasma membrane. The gene functions in centriole migration to the apical membrane and formation of the primary cilium. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Meckel syndrome type 3 (MKS3) and Joubert syndrome type 6 (JBTS6). [provided by RefSeq, Nov 2008]
UniProt Comments for TMEM67
Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (). Involved in centrosome migration to the apical cell surface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC).
Research Articles on TMEM67
1. Importantly, one Japanese and one Omani families carried compound biallelic mutations in two distinct genes (TMEM67/RPGRIP1L and TMEM138/BBS1, respectively).
Precautions
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Disclaimer
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